The ruthenium-catalyzed azide alkyne cycloaddition (RuAAC) affords 1, 5-disubstituted 1, 2,
3-triazoles in one step and complements the more established copper-catalyzed reaction …

Pioneered by Huisgen in the 1960s, 1 the 1, 3-dipolar cycloaddition reaction between
acetylenes and azides was brought back into focus by Sharpless and others2 when they …

Dipolar cycloaddition reactions can be considered a powerful synthetic tool in the building of
heterocyclic rings, with applications in different fields. In this review we focus on the …

Direct and rapid heating by microwave irradiation in combination with sealed vessel
processing in many cases enables reactions to be carried out in a fraction of the time …

First described almost a decade ago,“click” reactions such as the Cu (I)-catalyzed azide–
alkyne cycloaddition (CuAAC) are widely used today in organic and medicinal chemistry, in …

In the present perspective the advances and real possibilities of 1, 3-dipolar cycloadditions
as key steps in the total synthesis of virus inhibitors are described. Azides, nitrones, and …

Adenosine diphosphate ribosylation (ADP-ribosylation) is a crucial post-translational
modification involved in important regulatory mechanisms of numerous cellular pathways …

An experimentally simple sequential one-pot RuAAC reaction, affording 1, 5-disubstituted 1
H-1, 2, 3-triazoles in good to excellent yields starting from an alkyl halide, sodium azide, and …

The need for precise and flexible synthetic methodology to underpin modern research in
chemical biology and materials science has fuelled a resurgence of interest in Huisgen 1, 3 …

In whatever state of bonding–whether covalent to an organic residue or a heteroatom, or
polar to ionic in contact with a metal–the azide moiety N3 is characterized by its high …