Viruses have been engineered for cancer therapy in a variety of ways. Approaches include
non-replicating gene therapy vectors, cancer vaccines and oncolytic viruses, but the clinical …

It has been 9 years since the beginning of the first clinical trial in which an oncolytic virus
was administered to cancer patients. Since then, oncolytic viruses from five different species …

Genetically encoded imaging reporters introduced into cells and transgenic animals enable
noninvasive, longitudinal studies of dynamic biological processes in vivo. The most common …

Pertechnetate (as 99mTcO4−), 123I−, and 131I− have a long and successful history of use in
the diagnosis and therapy of thyroid cancer, with uptake into thyroid tissue mediated by the …

Clinical trials of new cancer drugs should ideally include measurements of parameters such
as molecular target expression, pharmacokinetic (PK) behavior, and pharmacodynamic (PD) …

Preclinical and clinical tomographic imaging systems increasingly are being utilized for non-
invasive imaging of reporter gene products to reveal the distribution of molecular …

The Na+/I− symporter (NIS) is a plasma membrane glycoprotein that mediates active iodide
uptake in the thyroid—the essential first step in thyroid hormone biosynthesis—and in other …

The first reporter systems were developed in the early 1980s and were based on measuring
the activity of an enzyme—as a surrogate measure of promoter-driven transcriptional activity …

To monitor noninvasively potentially therapeutic adenoviruses for cancer, we have
developed a methodology based on the sodium iodide symporter (NIS). Men with clinically …

The clinical application of positron-emission-tomography-based reporter gene imaging will
expand over the next several years. The translation of reporter gene imaging technology into …