The ability to adapt to changing internal and external conditions is a key feature of biological
systems. Homeostasis refers to a regulatory process that stabilizes dynamic systems to …

Highlights•Homeostatic signaling regulates-specific presynaptic mechanisms.•Work in
Drosophila has implicated several genes in presynaptic homeostatic plasticity.•Presynaptic …

Reactive oxygen species (ROS) have been extensively studied as damaging agents
associated with ageing and neurodegenerative conditions. Their role in the nervous system …

Animal behavior is remarkably robust despite constant changes in neural activity.
Homeostatic plasticity stabilizes central nervous system (CNS) function on time scales of …

To identify conserved components of synapse function that are also associated with human
diseases, we conducted a genetic screen. We used the Drosophila melanogaster …

Synapses and circuits rely on neuroplasticity to adjust output and meet physiological needs.
Forms of homeostatic synaptic plasticity impart stability at synapses by countering …

Presynaptic homeostatic plasticity (PHP) stabilizes synaptic transmission by counteracting
impaired neurotransmitter receptor function through neurotransmitter release potentiation …

Introduction: The ability of synapses to maintain physiological levels of evoked
neurotransmission is essential for neuronal stability. A variety of perturbations can disrupt …

The octomeric exocyst complex governs the final step of exocytosis in both plants and
animals. Its roles, however, extend beyond exocytosis and include organelle biogenesis …

Background Insect pest control programs often use periods of insecticide treatment with
intermittent breaks, to prevent fixing of mutations conferring insecticide resistance. Such …