Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin,
phenotypic and functional heterogeneity, are the most essential components of the tumor …

The functions of, and interactions between, the innate and adaptive immune systems are
vital for anticancer immunity. Cytotoxic T cells expressing cell-surface CD8 are the most …

To identify novel cancer therapies, the tumor microenvironment (TME) has received a lot of
attention in recent years in particular with the advent of clinical successes achieved by …

Among all the stromal cells that present in the tumor microenvironment, cancer-associated
fibroblasts (CAFs) are one of the most abundant and critical components of the tumor …

Cancer-associated fibroblasts (CAFs) are prominent components of the microenvironment in
most types of solid tumors, and were shown to facilitate cancer progression by supporting …

Fibroblasts play an essential role in organogenesis and the integrity of tissue architecture
and function. Growth in most solid tumors is dependent upon remodeling 'stroma', composed …

The highly complex and heterogenous ecosystem of a tumour not only contains malignant
cells, but also interacting cells from the host such as endothelial cells, stromal fibroblasts …

Intestinal mesenchymal cells play essential roles in epithelial homeostasis, matrix
remodeling, immunity, and inflammation. But the extent of heterogeneity within the colonic …

The tumour microenvironment, also termed the tumour stroma or tumour mesenchyme,
includes fibroblasts, immune cells, blood vessels and the extracellular matrix and …

Among all cells, fibroblasts could be considered the cockroaches of the human body. They
survive severe stress that is usually lethal to all other cells, and they are the only normal cell …