Nonspecific binding—fundamental concepts and consequences for biosensing applications

A Frutiger, A Tanno, S Hwu, RF Tiefenauer… - Chemical …, 2021 - ACS Publications
Nature achieves differentiation of specific and nonspecific binding in molecular interactions
through precise control of biomolecules in space and time. Artificial systems such as …

Glycomimetics versus multivalent glycoconjugates for the design of high affinity lectin ligands

S Cecioni, A Imberty, S Vidal - Chemical reviews, 2015 - ACS Publications
One could certainly highlight a conceptual resemblance between social interactions as the
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …

Multivalency as a chemical organization and action principle

C Fasting, CA Schalley, M Weber… - Angewandte Chemie …, 2012 - Wiley Online Library
Multivalent interactions can be applied universally for a targeted strengthening of an
interaction between different interfaces or molecules. The binding partners form cooperative …

Nanoscale forces and their uses in self‐assembly

KJM Bishop, CE Wilmer, S Soh, BA Grzybowski - small, 2009 - Wiley Online Library
The focus of nanoscience and nanotechnology is gradually shifting from the synthesis of
individual components to their assembly into larger systems and nanostructured materials …

Binding mechanisms in supramolecular complexes

HJ Schneider - Angewandte Chemie International Edition, 2009 - Wiley Online Library
Forces to reckon with: Supramolecular complexes, such as the one shown, are normally
based on a combination of different interactions such as ion pairing, hydrogen bonds, and …

Heteromultivalent peptide recognition by co-assembly of cyclodextrin and calixarene amphiphiles enables inhibition of amyloid fibrillation

Z Xu, S Jia, W Wang, Z Yuan, B Jan Ravoo, DS Guo - Nature chemistry, 2019 - nature.com
Heteromultivalency, which involves the simultaneous interactions of more than one type of
ligand with more than one type of receptor, is ubiquitous in living systems and provides a …

Designing super selectivity in multivalent nano-particle binding

FJ Martinez-Veracoechea… - Proceedings of the …, 2011 - National Acad Sciences
A key challenge in nano-science is to design ligand-coated nano-particles that can bind
selectively to surfaces that display the cognate receptors above a threshold (surface) …

Multivalency and cooperativity in supramolecular chemistry

JD Badjić, A Nelson, SJ Cantrill… - Accounts of chemical …, 2005 - ACS Publications
Multivalent interactions, which rely upon noncovalent bonds, are essential ingredients in the
mediation of biological processes, as well as in the construction of complex (super) …

Pathogen inhibition by multivalent ligand architectures

S Bhatia, LC Camacho, R Haag - Journal of the American …, 2016 - ACS Publications
Interfacial multivalent interactions at pathogen–cell interfaces can be competitively inhibited
by multivalent scaffolds that prevent pathogen adhesion to the cells during the initial stages …

[HTML][HTML] A quantitative view on multivalent nanomedicine targeting

L Woythe, NB Tito, L Albertazzi - Advanced drug delivery reviews, 2021 - Elsevier
Although the concept of selective delivery has been postulated over 100 years ago, no
targeted nanomedicine has been clinically approved so far. Nanoparticles modified with …