Mutations are at the root of many human diseases. Still, we largely do not exactly
understand how they trigger pathogenesis. One, more recent, hypothesis has been that they …

TDP-43 is the primary or secondary pathological hallmark of neurodegenerative diseases,
such as amyotrophic lateral sclerosis, half of frontotemporal dementia cases, and limbic age …

Amyotrophic lateral sclerosis (ALS) is the third most frequent neurodegenerative disease
after Alzheimer's and Parkinson's disease. ALS is characterized by the selective and …

Membrane proteins control and shape membrane trafficking processes. The role of protein
structure in shaping cellular membranes is well established. However, a significant fraction …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a fatal disease, progressive nature
characterizes by loss of both upper and lower motor neuron functions. One of the major …

After four decades of prion protein research, the pressing questions in the literature remain
similar to the common existential dilemmas. Who am I? Some structural characteristics of the …

Amyloids are protein polymers that were initially linked to human diseases. Across the whole
Tree of Life, many disease-unrelated proteins are now emerging for which amyloids …

TDP-43 is the primary or secondary pathological hallmark of neurodegenerative diseases,
such as amyotrophic lateral sclerosis, half of frontotemporal dementia cases, and limbic age …

Protein aggregation and amyloidogenesis are closely associated with the pathogenesis of
neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) …

The urge to contain the symptoms, to positively affect or reverse the course of a disease and
even prevent diseases from occurring is a fundamental drive in todays research of …