The mitochondrial permeability transition (MPT) plays an important role in damage-induced
cell death, and agents inhibiting the MPT may have a therapeutic potential for treating …

Targets that are Ldifficult-to-drugL typically have binding sites that are large, highly lipophilic
or polar, flexible, flat or featureless [1]. They contain few opportunities for high affinity …

The new program Dyana (DYnamics Algorithm for Nmr Applications) for efficient calculation
of three-dimensional protein and nucleic acid structures from distance constraints and …

Chemical shifts of backbone atoms in proteins are exquisitely sensitive to local
conformation, and homologous proteins show quite similar patterns of secondary chemical …

A unique feature of chemical catalysis mediated by enzymes is that the catalytically reactive
atoms are embedded within a folded protein. Although current understanding of enzyme …

Internal protein dynamics are intimately connected to enzymatic catalysis. However, enzyme
motions linked to substrate turnover remain largely unknown. We have studied dynamics of …

RefDB is a secondary database of reference-corrected protein chemical shifts derived from
the BioMagResBank (BMRB). The database was assembled by using a recently developed …

Transverse relaxation-optimized spectroscopy (TROSY) yields greatly improved sensitivity
for multidimensional NMR experiments with aromatic spin systems in proteins. TROSY …

The growing number of protein structures solved at atomic resolution holds the promise of
further improvements in geometry-based validation parameters. Additionally, the estimated …

We report here a biochemical and structural characterization of domain 2 of the
nonstructural 5A protein (NS5A) from the JFH1 Hepatitis C virus strain and its interactions …