Reactive oxygen and nitrogen species (RONS) are generated through various endogenous
and exogenous processes; however, they are neutralized by enzymatic and non-enzymatic …

Current evidence links oxidative stress (OS) to male infertility, reduced sperm motility, sperm
DNA damage and increased risk of recurrent abortions and genetic diseases. A review of …

The importance of reactive oxygen species (ROS) has been gradually acknowledged over
the last four decades. Initially perceived as unwanted products of detrimental oxidative …

The aging process worsens the human body functions at multiple levels, thus causing its
gradual decrease to resist stress, damage, and disease. Besides changes in gene …

The small intestinal epithelium self-renews every four or five days. Intestinal stem cells
(Lgr5+ crypt base columnar cells (CBCs)) sustain this renewal and reside between …

Aging tissues experience a progressive decline in homeostatic and regenerative capacities,
which has been attributed to degenerative changes in tissue-specific stem cells, stem cell …

An appropriate balance between self-renewal and differentiation is crucial for stem cell
function during both early development and tissue homeostasis throughout life. Recent …

Reactive oxygen species (ROS) contribute to tissue damage and remodelling mediated by
the inflammatory response after injury. Here we show that ROS, which promote axonal …

SIRT6 belongs to the mammalian homologs of Sir2 histone NAD+-dependent deacylase
family. In rodents, SIRT6 deficiency leads to aging-associated degeneration of mesodermal …

The regenerative capabilities including self-renewal, migration and differentiation potentials
shift from the embryonic phase to the mature period of endogenous tendon stem/progenitor …