For better or worse: crosstalk of parvovirus and host DNA damage response

S Chen, F Liu, A Yang, K Shang - Frontiers in Immunology, 2024 - frontiersin.org
Parvoviruses are a group of non-enveloped DNA viruses that have a broad spectrum of
natural infections, making them important in public health. NS1 is the largest and most …

Structure and function of the parvoviral NS1 protein: a review

Q Xie, J Wang, C Gu, J Wu, W Liu - Virus Genes, 2023 - Springer
Parvoviruses possess a single-stranded DNA genome of about 5 kb, which contains two
open reading frames (ORFs), one encoding nonstructural (NS) proteins, the other capsid …

Parvovirus nonstructural protein 2 interacts with chromatin-regulating cellular proteins

S Mattola, K Salokas, V Aho, E Mäntylä… - PLoS …, 2022 - journals.plos.org
Autonomous parvoviruses encode at least two nonstructural proteins, NS1 and NS2. While
NS1 is linked to important nuclear processes required for viral replication, much less is …

Molecular typing of a novel canine parvovirus type 2a mutant circulating in Italy

F Mira, G Dowgier, G Purpari, D Vicari… - Infection, genetics and …, 2018 - Elsevier
Canine parvovirus (CPV) is the etiological agent of a severe viral disease of dogs. After its
emergence in late 1970s, the CPV original type (CPV-2) was rapidly and totally replaced by …

Viral nonstructural protein 1 induces mitochondrion-mediated apoptosis in mink enteritis virus infection

P Lin, Y Cheng, S Song, J Qiu, L Yi, Z Cao, J Li… - Journal of …, 2019 - Am Soc Microbiol
Mink enteritis virus (MEV), an autonomous parvovirus, causes acute hemorrhagic enteritis in
minks. The molecular pathogenesis of MEV infection has not been fully understood. In this …

Molecular Characterization and Evolutionary Analyses of Carnivore Protoparvovirus 1 NS1 Gene

F Mira, M Canuti, G Purpari, V Cannella, S Di Bella… - Viruses, 2019 - mdpi.com
Carnivore protoparvovirus 1 is the etiological agent of a severe disease of terrestrial
carnivores. This unique specie encompasses canine parvovirus type 2 (CPV-2) and feline …

Prevalence and characteristics of canine parvovirus type 2 in Henan Province, China

P Fu, D He, X Cheng, X Niu, C Wang, Y Fu… - Microbiology …, 2022 - Am Soc Microbiol
To investigate the epidemic profile and genetic diversity of canine parvovirus type 2 (CPV-2),
a total of 111 clinical samples collected from dogs suspected of CPV-2 infection in 10 cities …

Concepts to reveal parvovirus–nucleus interactions

S Mattola, S Hakanen, S Salminen, V Aho, E Mäntylä… - Viruses, 2021 - mdpi.com
Parvoviruses are small single-stranded (ss) DNA viruses, which replicate in the nucleoplasm
and affect both the structure and function of the nucleus. The nuclear stage of the parvovirus …

Novel mutation N588 residue in the NS1 protein of feline parvovirus greatly augments viral replication

L Li, Z Liu, R Liang, M Yang, Y Yan, Y Jiao… - Journal of …, 2024 - Am Soc Microbiol
Feline parvovirus (FPV) infection is highly fatal in felines. NS1, which is a key nonstructural
protein of FPV, can inhibit host innate immunity and promote viral replication, which is the …

Canine parvovirus and its non-structural gene 1 as oncolytic agents: mechanism of action and induction of anti-tumor immune response

R Arora, WA Malla, A Tyagi, S Mahajan… - Frontiers in …, 2021 - frontiersin.org
The exploration into the strategies for the prevention and treatment of cancer is far from
complete. Apart from humans, cancer has gained considerable importance in animals …