The role of oxytocin in abnormal brain development: effect on glial cells and neuroinflammation

M Knoop, ML Possovre, A Jacquens, A Charlet, O Baud… - Cells, 2022 - mdpi.com
The neonatal period is critical for brain development and determinant for long-term brain
trajectory. Yet, this time concurs with a sensitivity and risk for numerous brain injuries …

Astrocytes as Drivers and Disruptors of Behavior: New Advances in Basic Mechanisms and Therapeutic Targeting

D Barnett, K Bohmbach, V Grelot, A Charlet… - Journal of …, 2023 - Soc Neuroscience
Astrocytes are emerging as key regulators of cognitive function and behavior. This review
highlights some of the latest advances in the understanding of astrocyte roles in different …

Oxytocin alleviates cognitive and memory impairments by decreasing hippocampal microglial activation and synaptic defects via OXTR/ERK/STAT3 pathway in a …

J Jiang, Y Zou, C Xie, M Yang, Q Tong, M Yuan… - Brain, Behavior, and …, 2023 - Elsevier
Background Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction,
characterized by cognitive and memory impairments closely linked to hippocampal …

Oxytocin receptors in the Magel2 mouse model of autism: Specific region, age, sex and oxytocin treatment effects

V Gigliucci, M Busnelli, F Santini, C Paolini… - Frontiers in …, 2023 - frontiersin.org
The neurohormone oxytocin (OXT) has been implicated in the regulation of social behavior
and is intensively investigated as a potential therapeutic treatment in neurodevelopmental …

Norepinephrine signals through astrocytes to modulate synapses

KB Lefton, Y Wu, A Yen, T Okuda, Y Zhang, Y Dai… - …, 2024 - pmc.ncbi.nlm.nih.gov
Locus coeruleus (LC)-derived norepinephrine (NE) drives network and behavioral
adaptations to environmental saliencies by reconfiguring circuit connectivity, but the …

Heteromerization of dopamine D2 and oxytocin receptor in adult striatal astrocytes

S Amato, M Averna, D Guidolin, C Ceccoli… - International Journal of …, 2023 - mdpi.com
The ability of oxytocin (OT) to interact with the dopaminergic system through facilitatory D2-
OT receptor (OTR) receptor-receptor interaction in the limbic system is increasingly …

The role of oxytocin in Early-Life-Stress-Related neuropsychiatric disorders

Y Jin, D Song, Y Yan, Z Quan, H Qing - International Journal of Molecular …, 2023 - mdpi.com
Early-life stress during critical periods of brain development can have long-term effects on
physical and mental health. Oxytocin is a critical social regulator and anti-inflammatory …

Neuromodulatory functions exerted by oxytocin on different populations of hippocampal neurons in rodents

F Talpo, P Spaiardi, AN Castagno… - Frontiers in Cellular …, 2023 - frontiersin.org
Oxytocin (OT) is a neuropeptide widely known for its peripheral hormonal effects (ie,
parturition and lactation) and central neuromodulatory functions, related especially to social …

[HTML][HTML] Dual oxytocin receptor-G protein signaling in the autoregulation of activities of oxytocin neurons

XY Liu, S Ling, Y Liu, S Jia, X Wang, T Li, D Li… - …, 2024 - karger.com
Oxytocin (OT), a hypothalamic nonaneuropeptide, can extensively modulate mental and
physical activities; however, the regulation of its secretion from hypothalamic OT neurons …

The Oxytocin Puzzle: Unlocking Alzheimer's Disease

MC Selles, MM Oliveira - Journal of Alzheimer's Disease, 2024 - content.iospress.com
Alzheimer's disease is a multi-factorial disease that disrupts many aspects of human
behavior. In this comment, we highlight the work by Koulousakis et al. published in a recent …