Reactive species produced in the cell during normal cellular metabolism can chemically
react with cellular biomolecules such as nucleic acids, proteins, and lipids, thereby causing …

Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …

Neurofibrillary tangles and amyloid plaques constitute the hallmark brain lesions of
Alzheimer's disease (AD) patients. Tangles are composed of fibrillar aggregates of the …

Astrocytes are glial cells that are distributed throughout the central nervous system in an
arrangement optimal for chemical and physical interaction with neuronal synapses and …

One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …

Oxidative stress (OS) has been implicated in the pathophysiology of many neurological,
particularly neurodegenerative diseases. OS can cause cellular damage and subsequent …

beta-Amyloid (beta A) is normally produced as a nontoxic soluble peptide. In Alzheimer
disease, beta A aggregates and accumulates in the brain as inert diffuse plaques or …

beta-Amyloid precursor protein (beta-APP), the source of the fibrillogenic amyloid beta-
peptide (A beta) that accumulates in the brain of victims of Alzheimer's disease, is a …

Alzheimer's disease, the major dementing disorder of the elderly that affects over 4 million
Americans, is related to amyloid β-peptide, the principal component of senile plaques in …

The molecular mechanism responsible for the neurodegeneration in Alzheimer disease is
not known; however, accumulating evidence suggests that beta-amyloid peptide (A beta P) …