Mass spectrometry (MS) is one of the most widely used analytical techniques in many fields.
Recent developments in chemical and biological researches have drawn much attention to …

Metabolomics has grown into a prominent field contributing to the molecular understanding
of complex biological processes in both health and disease. Furthermore, single-cells are …

Owing to recent advances in mass spectrometry (MS), tens to hundreds of proteins, lipids,
and small molecules can be measured in single cells. The ability to characterize the …

Circulating tumor cells (CTCs) are recognized as direct seeds of metastasis. However, CTC
count may not be the “best” indicator of metastatic risk because their heterogeneity is …

Cell manipulation is the foundation of biochemical studies, which demands user-friendly,
multifunctional and precise tools. Based on flow confinement principles, open microfluidics …

Cells are the fundamental units of biological systems and exhibit unique development
trajectories and molecular features. Our exploration of how the genomes orchestrate the …

Cellular heterogeneity is a phenomenon that is often observed but poorly understood.
Single-cell metabolomics can provide insights into the phenotypical variations between …

Heterogeneity in cell populations is a phenomenon encountered in virtually all biological
systems, in whole tissues and cell cultures and from bacterial to mammalian cells. Moreover …

Mass spectrometry (MS) based techniques are gaining popularity for metabolomics research
due to their high sensitivity, wide detection range, and capability of molecular identification …

Mass-spectrometry based omics technologies–namely proteomics, metabolomics and
lipidomics–have enabled the molecular level systems biology investigation of organisms in …