Executive summary The number of older people, including those living with dementia, is
rising, as younger age mortality declines. However, the age-specific incidence of dementia …

The locus coeruleus (LC), or 'blue spot', is a small nucleus located deep in the brainstem
that provides the far-reaching noradrenergic neurotransmitter system of the brain. This …

Psychosis is a common and distressing symptom in people with Alzheimer disease, and few
safe and effective treatments are available. However, new approaches to symptom …

Neuropsychiatric symptoms (NPSs) are common in patients with Alzheimer's disease (AD)
and are associated with accelerated cognitive impairment and earlier deaths. This review …

Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

Importance The behavioral variant of Alzheimer disease (bvAD) is characterized by early
and predominant behavioral deficits caused by AD pathology. This AD phenotype is …

Introduction Although dementia prevalence differs by race, it remains unclear whether
cognition and neuropsychiatric symptom severity differ between Black and White individuals …

Alzheimer's disease (AD) is the most common form of dementia. AD brain pathology starts
decades before the onset of clinical symptoms. One early pathological hallmark is blood …

Patients with Alzheimer's disease (AD) exhibit progressive memory loss, depression, and
anxiety, accompanied by impaired adult hippocampal neurogenesis (AHN). Whether AHN …

Although Alzheimer's disease (AD) is primarily a neurocognitive disorder, it also results in
prominent neuropsychiatric symptoms (NPS). Much literature has investigated the NPS of …