Primary lymphomas of the central nervous system (PCNSL) are mainly diffuse large B-cell
lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of …

B-cell receptor (BCR) is a B cell hallmark surface complex regulating multiple cellular
processes in normal as well as malignant B cells. Igα (CD79a)/Igβ (CD79b) are essential …

Ocular cancers represent a rare pathology. The American Cancer Society estimates that
3,360 cases of ocular cancer occur annually in the United States. The major types of cancers …

Activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL) is driven by aberrant
activation of the B-cell receptor (BCR) and the TLR/MyD88 signaling pathways. The heat …

Background Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-
Hodgkin lymphoma, and about 10% of DLBCL cases primarily occur in the gastrointestinal …

Cancer is one of the leading global causes of death and disease, and treatment options are
constantly evolving. In this sense, the use of monoclonal antibodies (mAbs) in …

Background The International Prognostic Index (IPI) is widely used to discriminate the
prognosis of patients with diffuse large B-cell lymphoma (DLBCL). However, there is a …

Background and aims Limited data are available for tumor immune microenvironment
(TIME) in Epstein–Barr virus (EBV)-associated lymphoepithelioma-like cholangiocarcinoma …

The ubiquitous, early‐stage expression, efficient internalization, limited off‐target effects,
and high disease specificity of CD19 make it an attractive therapeutic target. Currently …

Primary Central Nervous System Lymphoma (PCNSL) is a lymphoid malignancy of the brain
that occurs in~ 1500 patients per year in the US. PCNSL can spread to the vitreous and …