An update regarding the role of WNK kinases in cancer
M Xiu, L Li, Y Li, Y Gao - Cell Death & Disease, 2022 - nature.com
Mammalian WNK kinases (WNKs) are serine/threonine kinases that contain four members,
WNK1–4. They function to maintain ion homeostasis and regulate blood pressure in …
WNK1–4. They function to maintain ion homeostasis and regulate blood pressure in …
Finding inhibitors and deciphering inhibitor-induced conformational plasticity in the Janus kinase via multiscale simulations
MF Sk, P Kar - SAR and QSAR in Environmental Research, 2022 - Taylor & Francis
The Janus kinase (JAK) is a master regulator of the JAK/STAT pathway. Dysregulation of this
signalling cascade causes neuroinflammation and autoimmune disorders. Therefore, JAKs …
signalling cascade causes neuroinflammation and autoimmune disorders. Therefore, JAKs …
Exploring molecular interactions of potential inhibitors against the spleen tyrosine kinase implicated in autoimmune disorders via virtual screening and molecular …
The spleen tyrosine kinase (Syk) plays a pivotal role in immune cells' signal transduction
mechanism. While fostamatinib, an FDA-approved Syk inhibitor, is currently used to treat …
mechanism. While fostamatinib, an FDA-approved Syk inhibitor, is currently used to treat …
Multilayered screening for multi-targeted anti-Alzheimer's and anti-Parkinson's agents through structure-based pharmacophore modelling, MCDM, docking, molecular …
N Chhabra, BW Matore, N Lakra, P Banjare… - In Silico …, 2025 - Springer
Alzheimer's disease (AD) and Parkinson's disease (PD) are neurological conditions that
primarily impact the elderly having distinctive traits and some similarities in terms of …
primarily impact the elderly having distinctive traits and some similarities in terms of …
Elucidating the conformational dynamics of histo-blood group antigens and their interactions with the rotavirus spike protein through computational lens
In the present study, we investigated the conformational dynamics of histo-blood group
antigens (HBGAs) and their interactions with the VP8* domain of four rotavirus genotypes (P …
antigens (HBGAs) and their interactions with the VP8* domain of four rotavirus genotypes (P …