Abstract The TRP (Transient Receptor Potential) superfamily of cation channels is
remarkable in that it displays greater diversity in activation mechanisms and selectivities …

The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …

Ca 2+ signaling in nonexcitable cells is typically initiated by receptor-triggered production of
inositol-1, 4, 5-trisphosphate and the release of Ca 2+ from intracellular stores [1]. An elusive …

Store-operated Ca2+ (SOC) channels regulate many cellular processes, but the underlying
molecular components are not well defined. Using an RNA interference (RNAi)-based …

The concentration of Ca 2+ in the endoplasmic reticulum (ER) is critically important for
maintaining its oxidizing environment as well as for maintaining luminal ATP levels required …

The 28 mammalian members of the super-family of transient receptor potential (TRP)
channels are cation channels, mostly permeable to both monovalent and divalent cations …

The TRP (“transient receptor potential”) family of ion channels now comprises more than 30
cation channels, most of which are permeable for Ca2+, and some also for Mg2+. On the …

Stromal interacting molecule 1 (STIM1), reported to be an endoplasmic reticulum (ER) Ca2+
sensor controlling store-operated Ca2+ entry, redistributes from a diffuse ER localization into …

BACKGROUND Uterine contractile activity plays an important role in many and varied
reproductive functions including sperm and embryo transport, implantation, menstruation …

▪ Abstract Ion channels are pore-forming transmembrane proteins that allow ions to
permeate biological membranes. Pore structure plays a crucial role in determining the ion …