Alginates as a useful natural polymer for microencapsulation and therapeutic applications

CH Goh, PWS Heng, LW Chan - Carbohydrate polymers, 2012 - Elsevier
This review outlines the role of alginates in microencapsulation and therapeutic
applications. It focuses on the physicochemical properties of alginates (eg viscosity, thermo …

Unraveling particle formation: From single droplet drying to spray drying and electrospraying

E Boel, R Koekoekx, S Dedroog, I Babkin, MR Vetrano… - Pharmaceutics, 2020 - mdpi.com
Spray drying and electrospraying are well-established drying processes that already have
proven their value in the pharmaceutical field. However, there is currently still a lack of …

In-depth determination and analysis of the human paired heavy-and light-chain antibody repertoire

BJ DeKosky, T Kojima, A Rodin, W Charab… - Nature medicine, 2015 - nature.com
High-throughput immune repertoire sequencing has emerged as a critical step in the
understanding of adaptive responses following infection or vaccination or in autoimmunity …

Physical approaches to biomaterial design

S Mitragotri, J Lahann - Nature materials, 2009 - nature.com
The development of biomaterials for drug delivery, tissue engineering and medical
diagnostics has traditionally been based on new chemistries. However, there is growing …

Particle shape: a new design parameter for micro-and nanoscale drug delivery carriers

JA Champion, YK Katare, S Mitragotri - Journal of controlled release, 2007 - Elsevier
Encapsulation of therapeutic agents in polymer particles has been successfully used in the
development of new drug carriers. A number of design parameters that govern the functional …

Polymer microspheres for controlled drug release

S Freiberg, XX Zhu - International journal of pharmaceutics, 2004 - Elsevier
Polymer microspheres can be employed to deliver medication in a rate-controlled and
sometimes targeted manner. Medication is released from a microsphere by drug leaching …

Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles

C Wischke, SP Schwendeman - International Journal of pharmaceutics, 2008 - Elsevier
Injectable biodegradable and biocompatible copolymers of lactic and glycolic acid (PLGA)
are an important advanced delivery system for week-to-month controlled release of …

Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology

S Freitas, HP Merkle, B Gander - Journal of controlled release, 2005 - Elsevier
The therapeutic benefit of microencapsulated drugs and vaccines brought forth the need to
prepare such particles in larger quantities and in sufficient quality suitable for clinical trials …

Effect of particle size on drug loading and release kinetics of gefitinib-loaded PLGA microspheres

W Chen, A Palazzo, WE Hennink… - Molecular …, 2017 - ACS Publications
Polymeric microspheres have gained widespread application as drug eluting depots.
Typically, drug-loaded polymeric microspheres are prepared by oil-in-water emulsification …

Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow‐focusing device for controlled drug delivery

Q Xu, M Hashimoto, TT Dang, T Hoare, DS Kohane… - small, 2009 - Wiley Online Library
Degradable microparticles have broad utility as vehicles for drug delivery and form the basis
of several therapies approved by the US Food and Drug Administration. Conventional …