A comprehensive review on redox reactions of Co (III), Co (II) and Co (I) forms of cobalamins
(vitamin B12) and their derivatives (cobinamide, cobyrinates) is presented. An influence of …

The inorganic chemistry of the cobalt corrinoids, derivatives of vitamin B 12, is reviewed, with
particular emphasis on equilibrium constants for, and kinetics of, their axial ligand …

The existence of cobalamin (Cbl)-dependent enzymes that are members of the radical S-
adenosyl-l-methionine (SAM) superfamily was previously predicted on the basis of …

[FeFe] hydrogenases are highly active enzymes for interconverting protons and electrons
with hydrogen (H2). Their active site H-cluster is formed of a canonical [4Fe-4S] cluster ([4Fe …

Despite the unique reactivity of vitamin B12 and its derivatives, B12‐dependent enzymes
remain underutilized in biocatalysis. In this study, we repurposed the B12‐dependent …

TsrM, an annotated radical S-adenosylmethionine (SAM) enzyme, catalyzes the methylation
of carbon 2 of the indole ring of l-tryptophan. Its reaction is the first step in the biosynthesis of …

Vitamins are organic molecules that are essential for the proper functioning of mammalian
cells. Among them, there is only one organometallic molecule: vitamin B 12, a natural cobalt …

The biosynthesis of branched alkoxy groups, such as the unique t-butyl group found in a
variety of natural products, is still poorly understood. Recently, cystobactamids were isolated …

Aquacobalamin binds hydrogen peroxide reversibly to form a cobalt (III) hydroperoxo adduct
with a 0.25 mM dissociation constant, as evidenced by UV–vis absorption spectroscopy and …

OxsB is a B12-dependent radical SAM enzyme that catalyzes the oxidative ring contraction
of 2′-deoxyadenosine 5′-phosphate to the dehydrogenated, oxetane containing …