For nearly 50 years the proximal tubule (PT) has been known to reabsorb, process, and
either catabolize or transcytose albumin from the glomerular filtrate. Innovative techniques …

Proximal tubule protein uptake is mediated by 2 receptors, megalin and cubilin. These
receptors rescue a variety of filtered ligands, including biomarkers, essential vitamins, and …

Reduced glomerular filtration rate defines chronic kidney disease and is associated with
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …

Protein reabsorption is a predominant feature of the renal proximal tubule. Animal studies
show that the ability to rescue plasma proteins relies on the endocytic receptors megalin and …

Peptide-receptor radionuclide therapy (PRRT) with radiolabeled somatostatin analogs such
as octreotide is an effective therapy against neuroendocrine tumors. Other radiolabeled …

Cobalamin (vitamin B12) deficiency is particularly common in the elderly (> 65 years of age),
but is often unrecognized because of its subtle clinical manifestations; although they can be …

While pluripotent stem cell-derived kidney organoids are now being used to model renal
disease, the proximal nephron remains immature with limited evidence for key functional …

Identification of genetic risk factors for albuminuria may alter strategies for early prevention
of CKD progression, particularly among patients with diabetes. Little is known about the …

Cells lining the proximal tubule (PT) of the kidney are highly specialized for apical
endocytosis of filtered proteins and small bioactive molecules from the glomerular …

Proteins filtered in renal glomeruli are removed from the tubular fluid by endocytosis in the
proximal tubule mediated by the two receptors megalin and cubilin. After endocytic uptake …