Abstract Objectives Healthcare organizations, including Clinical and Translational Science
Awards (CTSA) hubs funded by the National Institutes of Health, seek to enable secondary …

Abstract Objective Approved by the Food and Drug Administration (FDA) in 2017 for
diabetes and in 2021 for weight loss, semaglutide has seen widespread use among …

Hypertension control remains poor. Multiple barriers at the level of patients, providers, and
health systems interfere with implementation of hypertension guidelines and effective …

Abstract PCORnet, the National Patient-Centered Clinical Research Network, provides the
ability to conduct prospective and observational pragmatic research by leveraging …

Background: Electronic health record (EHR) data have many quality problems that may
affect the outcome of research results and decision support systems. Many methods have …

Objective Population-level data on sickle cell disease (SCD) are sparse in the United States.
The Centers for Disease Control and Prevention (CDC) is addressing the need for SCD …

COVID-19 infection has resulted in significant morbidity and mortality globally, especially
among older adults. Repurposed drugs have demonstrated activity in respiratory illnesses …

Background: Obesity is associated with obstructive sleep apnoea (OSA) and cardiovascular
risk. Positive airway pressure (PAP) is the first line treatment for OSA, but evidence on its …

The use of electronic health records has garnered interest as an approach for conducting
innovative outcome research and producing real-world evidence at a reduced cost …

Research Patient Data Repositories (RPDRs) have become essential infrastructure for
traditional Clinical and Translational Science Award (CTSA) programs and increasingly for a …