Synapses are essential components of neurons and allow information to travel coordinately
throughout the nervous system to adjust behavior to environmental stimuli and to control …

Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central
to the aetiology of Parkinson's disease, a considerable amount of work has gone into …

Cytoskeletal homeostasis is essential for the development, survival and maintenance of an
efficient nervous system. Microtubules are highly dynamic polymers important for neuronal …

Parkinson's disease (PD) is the second most common neurodegenerative disorder, leading
to a variety of motor and non-motor symptoms. Interestingly, non-motor symptoms often …

Mutations in LRRK2 are a common cause of familial and idiopathic Parkinson's disease
(PD). Recently, the LRRK2 GTPase domain R1398H variant was suggested in genetic …

Background LRRK2 mutations and risk variants increase susceptibility to inherited and
idiopathic Parkinson's disease, while recent studies have identified potential protective …

As a proliferative and restorative entity, Wnt1 inducible signaling pathway protein 1 (WISP1)
is emerging as a novel target for a number of therapeutic strategies that are relevant for …

Developmental signalling pathways such as Wnt/β-catenin, Notch and Sonic hedgehog play
a central role in nearly all the stages of neuronal development. The term 'embryonic'might …

Significant advances have been made in the understanding of the numerous mechanisms
involved in Parkinson's disease (PD) pathogenesis. The identification of PD pathogenic …

Abstract Wingless/Int (Wnt) signaling pathways are signal transduction mechanisms that
have been widely studied in the field of embryogenesis. Recent work has established a …