Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

S Ji, M Xiong, H Chen, Y Liu, L Zhou, Y Hong… - … and Targeted Therapy, 2023 - nature.com
The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

Acellular human lung scaffolds to model lung disease and tissue regeneration

SE Gilpin, DE Wagner - European Respiratory Review, 2018 - Eur Respiratory Soc
Recent advances in whole lung bioengineering have opened new doors for studying lung
repair and regeneration ex vivo using acellular human derived lung tissue scaffolds …

Development of a physiomimetic model of acute respiratory distress syndrome by using ECM hydrogels and organ-on-a-chip devices

E Marhuenda, A Villarino, M Narciso… - Frontiers in …, 2022 - frontiersin.org
Acute Respiratory Distress Syndrome is one of the more common fatal complications in
COVID-19, characterized by a highly aberrant inflammatory response. Pre-clinical models to …

Recent frontiers in biofabrication for respiratory tissue engineering

A Zimmerling, NA Dahlan, Y Zhou, X Chen - Bioprinting, 2024 - Elsevier
Respiratory tissue engineering offers a robust framework for studying cell-cell and host-
pathogen interactions in a tissue-like environment and offers a platform for studying lung …

Rat lung decellularization using chemical detergents for lung tissue engineering

H Tebyanian, A Karami, E Motavallian… - Biotechnic & …, 2019 - Taylor & Francis
Although pulmonary diseases account for a large number of deaths in the world, most have
no treatment other than transplantation. New therapeutic methods for lung treatment include …

Fibrosis in tissue engineering and regenerative medicine: treat or trigger?

A Fernandez-Colino, L Iop, MSV Ferreira… - Advanced Drug Delivery …, 2019 - Elsevier
Fibrosis is a life-threatening pathological condition resulting from a dysfunctional tissue
repair process. There is no efficient treatment and organ transplantation is in many cases the …

Transcriptional characterization of bronchoalveolar lavage fluid reveals immune microenvironment alterations in chemically induced acute lung injury

C Cao, O Memet, F Liu, H Hu, L Zhang… - Journal of …, 2023 - Taylor & Francis
Purpose Chemically induced acute lung injury (CALI) has become a serious health concern
in our industrialized world, and abnormal functional alterations of immune cells crucially …

Bioengineered lungs: a challenge and an opportunity

R Farré, J Otero, I Almendros, D Navajas - Archivos de bronconeumologia, 2018 - Elsevier
Lung biofabrication is a new tissue engineering and regenerative development aimed at
providing organs for potential use in transplantation. Lung biofabrication is based on …

Biological models of the lower human airways—challenges and special requirements of human 3D barrier models for biomedical research

C Wiese-Rischke, RS Murkar, H Walles - Pharmaceutics, 2021 - mdpi.com
In our review, we want to summarize the current status of the development of airway models
and their application in biomedical research. We start with the very well characterized …

Artificial lungs––Where are we going with the lung replacement therapy?

J Swol, N Shigemura, S Ichiba, U Steinseifer… - Artificial …, 2020 - Wiley Online Library
Lung transplantation may be a final destination therapy in lung failure, but limited donor
organ availability creates a need for alternative management, including artificial lung …