Statins are a cornerstone in the pharmacological prevention of cardiovascular disease.
Although generally well tolerated, a small subset of patients experience statin-related …

Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …

Abstract Cytochrome P450 3A4 (CYP3A4) metabolizes∼ 50% of all clinically used drugs.
Although CYP3A4 expression varies widely between individuals, the contribution of genetic …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

Palbociclib, ribociclib, and abemaciclib belong to the third generation of cyclin-dependent
kinases inhibitors (CDKis), an established therapeutic class for advanced and metastatic …

Statins are a cornerstone of the pharmacologic treatment and prevention of atherosclerotic
cardiovascular disease. Atherosclerotic disease is a predominant cause of mortality and …

Introduction: Lipid-lowering drugs, especially hydroxymethylglutaryl-CoA reductase
inhibitors (statins), are widely used in the treatment and prevention of atherosclerotic …

Abstract Statins, 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors, have proven
efficacy in both lowering low-density-lipoprotein levels and preventing major coronary …

The widespread applications of the century-old Michaelis-Menten kinetics in the
characterization of drug-metabolizing cytochrome P450 enzymes have persisted since their …

Atorvastatin, prescribed for the treatment of hypercholesterolemia, demonstrated
overwhelming benefits in reducing cardiovascular morbidity and mortality. However, many …