The last few years have witnessed an unprecedented increase in the number of novel
bacterial species that hold potential to be used for metabolic engineering. Historically …

ArcAB, also known as the Arc system, is a member of the two-component system family of
bacterial transcriptional regulators and is composed of sensor kinase ArcB and response …

The soil bacterium Pseudomonas putida KT2440 lacks a functional Embden-Meyerhof-
Parnas (EMP) pathway, and glycolysis is known to proceed almost exclusively through the …

Cofactors are involved in numerous intracellular reactions and critically influence redox
balance and cellular metabolism. Cofactor engineering can support and promote the …

Despite the importance of maintaining redox homeostasis for cellular viability, how cells
control redox balance globally is poorly understood. Here we provide new mechanistic …

Engineering a microbial strain for production sometimes entails metabolic modifications that
impair essential physiological processes for growth or production. Restoring these functions …

The CreBC (c arbon source-re sponsive) two-component regulation system of Escherichia
coli affects a number of functions, including intermediary carbon catabolism. The impacts of …

Bioprocesses conducted under conditions with restricted O 2 supply are increasingly
exploited for the synthesis of reduced biochemicals using different biocatalysts. The model …

Clostridium thermocellum and Thermoanaerobacterium saccharolyticum are bacteria under
investigation for production of biofuels from plant biomass. Thermoanaerobacterium …

Gram-negative facultative anaerobes often cause bacteremia, a systemic infection
associated with severe clinical outcomes. ArcAB, a two-component regulatory system that …