YAP and TAZ are highly related transcriptional regulators pervasively activated in human
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …

Abstract Merlin (Moesin-ezrin-radixin-like protein, also known as schwannomin) is a tumor
suppressor protein encoded by the neurofibromatosis type 2 gene NF2. Loss of function …

Abstract Neurofibromatosis type 2 (NF2) is a genetic condition marked by the development
of multiple benign tumors in the nervous system. The most common tumors associated with …

Purpose Neurofibromatosis type 2 (NF2) is a tumor predisposition syndrome characterized
by bilateral vestibular schwannomas (VSs) resulting in deafness and brainstem …

The Hippo pathway regulates cell proliferation and organ size through control of the
transcriptional regulators YAP (yes-associated protein) and TAZ. Upon extracellular stimuli …

Cell transplantation studies have shown that injection of progenitor cells can improve
cardiac function after myocardial infarction (MI). Transplantation of human cardiac progenitor …

Schwannomas are predominantly benign nerve sheath neoplasms caused by Nf2 gene
inactivation. Presently, treatment options are mainly limited to surgical tumor resection due …

Vestibular schwannomas (VSs, also known as acoustic neuromas) are relatively rare benign
brain tumors stem from the Schwann cells of the eighth cranial nerve. Tumor growth is the …

Understanding the molecular nature of human cancer is essential to the development of
effective and personalized therapies. Several different molecular signal transduction …

Purpose: The aims were two-fold: first, to examine the expression of Yes-activated protein
(YAP), a key Hippo pathway regulator, in clinical thyroid papillary carcinoma samples and to …