Ryanodine receptors (RyRs) are large Ca 2+ release channels residing in the endoplasmic
or sarcoplasmic reticulum membrane. Three isoforms of RyRs have been identified in …

Abstract Ryanodine Receptor isoform 3 (RyR3) is a large ion channel found in the
endoplasmic reticulum membrane of many different cell types. Within the hippocampal …

Hyperactivity of cardiac sarcoplasmic reticulum (SR) ryanodine receptor (RyR2) Ca2+-
release channels contributes to heart failure and arrhythmias. Reducing the RyR2 activity …

Ryanodine receptor type 1 (RyR1) is a Ca2+-release channel central to skeletal muscle
excitation–contraction (EC) coupling. RyR1's cryo-EM structures reveal a zinc-finger motif …

Background The unique ability of the respiratory tract to protect the integrity of the airways by
removing potentially harmful substances is defined as mucociliary clearance. This complex …

Intrinsically disordered regions (IDRs), which may be functionally important, are common in
proteins. However, the structures of IDRs are often missing due to their highly dynamic …

Abstract Background As the primary Ca 2+ release channel in skeletal muscle sarcoplasmic
reticulum (SR), mutations in type 1 ryanodine receptor (RyR1) or its binding partners …

Background Malignant hyperthermia (MH) susceptibility is associated with variants in RYR1,
the gene encoding the skeletal muscle ryanodine receptor-1 (RyR1), in 70–75% of patients …

Motivation: With the advancement of structural biology techniques, the elucidation of
increasingly large protein structures has become possible. However, the structural modeling …

Ryanodine receptors (RyRs) are intracellular tetrameric ion channels responsible for
calcium; release from the sarcoplasmic and endoplasmic reticulum. Among the three known …