Advances in SARS-CoV-2 receptor-binding domain-based COVID-19 vaccines

X Guan, Y Yang, L Du - Expert review of vaccines, 2023 - Taylor & Francis
ABSTRACT Introduction The Coronavirus Disease 2019 (COVID-19) pandemic has caused
devastating human and economic costs. Vaccination is an important step in controlling the …

Omicron (B. 1.1. 529) variant and its subvariants and lineages may lead to another COVID-19 wave in the world?-An overview of current evidence and counteracting …

R Sah, MA Rais, A Mohanty, H Chopra… - … Journal of Surgery …, 2023 - journals.lww.com
The highly contagious Omicron variant of SARS-CoV-2 is a recent cause of concern during
the COVID-19 pandemic. The World Health Organization (WHO) has classified SARS-CoV-2 …

Peptide delivery of a multivalent mRNA SARS-CoV-2 vaccine

CM McCrudden, L Bennie, P Chambers… - … Clinics and Research, 2023 - journals.lww.com
Lipid nanoparticles (LNP) have been instrumental in the success of mRNA vaccines and
have opened up the field to a new wave of therapeutics. However, what is ahead beyond the …

Glycosylated Delta-receptor-binding domain mucosal vaccine elicits broadly neutralizing antibodies with protection against SARS-CoV-2 challenge

X Guan, AK Verma, G Wang, J Shi, S Perlman, L Du - Iscience, 2023 - cell.com
Mucosal COVID-19 vaccines are needed to block SARS-CoV-2 infection at the mucosal site.
Intranasal delivery of a glycosylated Delta variant receptor-binding domain (Delta-RBD) …

Screening of efficient adjuvants for the RBD-based subunit vaccine of SARS-CoV-2

J Shi, Y Zhao, M Peng, S Zhu, Y Wu, R Ji, C Shen - Vaccines, 2023 - mdpi.com
The variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more
transmissible, with a reduced sensitivity to vaccines targeting the original virus strain …

[HTML][HTML] MERS-CoV RBD-mRNA vaccine induces potent and broadly neutralizing antibodies with protection against MERS-CoV infection

W Tai, J Zheng, X Zhang, J Shi, G Wang, X Guan, J Zhu… - Virus research, 2023 - Elsevier
Middle East respiratory syndrome coronavirus (MERS-CoV), a highly pathogenic
coronavirus in the same Betacoronavirus genus and Coronaviridae family as SARS-CoV-2 …

Safety and immunogenicity following the second and third doses of the BNT162b2 mRNA COVID-19 vaccine in adolescents with juvenile-onset autoimmune …

M Heshin-Bekenstein, A Ziv, N Toplak, S Lazauskas… - Vaccines, 2023 - mdpi.com
Background: To explore the long-term safety and dynamics of the immune response induced
by the second and third doses of the BNT162b2 mRNA COVID-19 vaccine in adolescents …

[HTML][HTML] AT cell–based SARS-CoV-2 spike protein vaccine provides protection without antibodies

J Shi, J Zheng, X Zhang, W Tai, R Compas, J Deno… - JCI insight, 2024 - ncbi.nlm.nih.gov
Abstract SARS-CoV-2 spike–based vaccines are used to control the COVID-19 pandemic.
However, emerging variants have become resistant to antibody neutralization and further …

Therapeutic nanobodies against SARS-CoV-2 and other pathogenic human coronaviruses

Y Yang, F Li, L Du - Journal of Nanobiotechnology, 2024 - Springer
Nanobodies, single-domain antibodies derived from variable domain of camelid or shark
heavy-chain antibodies, have unique properties with small size, strong binding affinity, easy …

A Unique mRNA Vaccine Elicits Protective Efficacy against the SARS-CoV-2 Omicron Variant and SARS-CoV

X Guan, AK Verma, G Wang, A Roy, S Perlman, L Du - Vaccines, 2024 - mdpi.com
The highly pathogenic coronaviruses SARS-CoV-2 and SARS-CoV have led to the COVID-
19 pandemic and SARS outbreak, respectively. The receptor-binding domain (RBD) of the …