Mitochondria are important organelles in eukaryotes. Turnover and quality control of
mitochondria are regulated at the transcriptional and posttranslational level by several …

Obesity is a growing public health problem, with its prevalence rate having tripled in the last
five decades. It has been shown that obesity is associated with alterations in cardiac energy …

Lysine acetylation is a conserved post-translational modification involved in energy
metabolism in mitochondria and heart function. This study investigates the role of …

Background The pulmonary surfactant that lines the air–liquid surface within alveoli is a
protein–lipid mixture essential for gas exchange. Surfactant lipids and proteins are …

The aberrant acetylation of mitochondrial proteins is involved in the pathogenesis of multiple
diseases including neurodegenerative diseases and cerebral ischemic injury. Previous …

Gcn5 serves as the defining member of the Gcn5-related N-acetyltransferase (GNAT)
superfamily of proteins that display a common structural fold and catalytic mechanism …

BACKGROUND: Nearly half of adults have hypertension, a major risk factor for
cardiovascular disease. Mitochondrial hyperacetylation is linked to hypertension, but the …

The phagocytosis and destruction of pathogens in lysosomes constitute central elements of
innate immune defense. Here, we show that Brucella, the causative agent of brucellosis, the …

BLOC1S1 is a common component of BLOC and BORC multiprotein complexes which play
distinct roles in endosome and lysosome biology. Recent human mutations in BLOC1S1 …

Ischemic stroke is a major cause of mortality and disability worldwide. Among patients with
ischemic stroke, the primary treatment goal is to reduce acute cerebral ischemic injury and …