Fibrin plays an essential role in hemostasis as both the primary product of the coagulation
cascade and the ultimate substrate for fibrinolysis. Fibrinolysis efficiency is greatly …

Phosphatidylserine (PS) is a major component of membrane bilayers whose change in
distribution between inner and outer leaflets is an important physiological signal. Normally …

Autoimmune disorders are often associated with low platelet count or thrombocytopenia. In
immune-induced thrombocytopenia (IIT), a common mechanism is increased platelet …

Platelets interact with the coagulation system in a multitude of ways, not only during the
phases of thrombus formation, but also in specific areas within a formed thrombus. This …

Treatment of bleeding disorders using transfusion of donor-derived platelets faces logistical
challenges due to their limited availability, high risk of contamination, and short (5 to 7 days) …

Phosphatidylserine (PtdSer) exposure on the surface of activated platelets requires the
action of a phospholipid scramblase (s), and serves as a scaffold for the assembly of the …

Traditionally, in vitro flow chamber experiments and in vivo arterial thrombosis studies have
been proved to be of vital importance to elucidate the mechanisms of platelet thrombus …

Atherosclerosis is the leading cause of death in the United States and worldwide, yet more
men die from atherosclerosis than women, and at a younger age. Women, on the other …

Red blood cells (RBCs) influence rheology, and release ADP, ATP, and nitric oxide,
suggesting a role for RBCs in hemostasis and thrombosis. Here, we provide evidence for a …

Autophagy is important for maintaining cellular homeostasis, and thus its deficiency is
implicated in a broad spectrum of human diseases. Its role in platelet function has only …