Alzheimer's disease (AD) is an age-related multifactorial neurodegenerative disorder.
Advances in genome technology, including next generation sequencing have uncovered …

Obesity has become a public health problem worldwide. Compared with Europe, people in
Asia tend to suffer from type 2 diabetes with a lower body mass index (BMI). Genome-wide …

Despite the great success of genome-wide association studies (GWAS) in identifying genetic
loci significantly associated with diseases, the vast majority of causal variants underlying …

The diversity in our genome is crucial to understanding the demographic history of
worldwide populations. However, we have yet to know whether subtle genetic differences …

Abstract The Iberian Peninsula is linguistically diverse and has a complex demographic
history, including a centuries-long period of Muslim rule. Here, we study the fine-scale …

Abstract The Funadomari Jomon people were hunter-gatherers living on Rebun Island,
Hokkaido, Japan c. 3500–3800 years ago. In this study, we determined the high-depth and …

Background Germline mutation in BRCA 1 and BRCA2 (BRCA) is genetic predisposition for
breast and ovarian cancer. Identification of mutation carriers is a critical step to prevent and …

The Hui people are unique among Chinese ethnic minorities in that they speak the same
language as Han Chinese (HAN) but practice Islam. However, as the second-largest …

Previous genetic studies have identified local population structure within the Netherlands;
however their resolution is limited by use of unlinked markers and absence of external …

Human natural killer (NK) cells are essential for controlling infection, cancer, and fetal
development. NK cell functions are modulated by interactions between polymorphic …