Over the past 10 years, the study of histone acetyltransferases (HATs) has advanced
significantly, and a number of HATs have been isolated from various organisms. It emerged …

The Mediator complex is a multi-subunit assembly that appears to be required for regulating
expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and …

Networks have become a key approach to understanding systems of interacting objects,
unifying the study of diverse phenomena including biological organisms and human …

In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …

Here we review recent advances in understanding the regulation of mRNA synthesis in
Saccharomyces cerevisiae. Many fundamental gene regulatory mechanisms have been …

Gene transcription by RNA polymerase II is regulated by activator proteins that recruit the
coactivator complexes SAGA (Spt–Ada–Gcn5–acetyltransferase), and transcription factor IID …

Transcription initiation is a major regulatory step in eukaryotic gene expression. Co-
activators establish transcriptionally competent promoter architectures and chromatin …

The SAGA (Spt–Ada–Gcn5 acetyltransferase) coactivator complex contains distinct
chromatin-modifying activities and is recruited by DNA-bound activators to regulate the …

Transcription in eukaryotes is a tightly regulated, multistep process. Gene-specific
transcriptional activators, several different co-activators and general transcription factors are …

Abstract SAGA (Spt–Ada–Gcn5–acetyltransferase) is a 19-subunit complex that stimulates
transcription via two chromatin-modifying enzymatic modules and by delivering the TATA …