Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments

Z Yuan, Y Li, S Zhang, X Wang, H Dou, X Yu, Z Zhang… - Molecular cancer, 2023 - Springer
The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Liposomes and extracellular vesicles as drug delivery systems: A comparison of composition, pharmacokinetics, and functionalization

L van der Koog, TB Gandek… - Advanced healthcare …, 2022 - Wiley Online Library
Over the past decades, lipid‐based nanoparticle drug delivery systems (DDS) have caught
the attention of researchers worldwide, encouraging the field to rapidly develop improved …

Extracellular vesicles and their emerging roles as cellular messengers in endocrinology: an endocrine society scientific statement

C Salomon, S Das, U Erdbrügger, R Kalluri… - Endocrine …, 2022 - academic.oup.com
During the last decade, there has been great interest in elucidating the biological role of
extracellular vesicles (EVs), particularly, their hormone-like role in cell-to-cell …

[HTML][HTML] Extracellular vesicles: Critical players during cell migration

BH Sung, CA Parent, AM Weaver - Developmental cell, 2021 - cell.com
Cell migration is essential for the development and maintenance of multicellular organisms,
contributing to embryogenesis, wound healing, immune response, and other critical …

Extracellular vesicle transportation and uptake by recipient cells: A critical process to regulate human diseases

ZH Kwok, C Wang, Y Jin - Processes, 2021 - mdpi.com
Emerging evidence highlights the relevance of extracellular vesicles (EVs) in modulating
human diseases including but not limited to cancer, inflammation, and neurological …

Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context

A Esmaeili, M Alini, M Baghaban Eslaminejad… - Stem Cell Research & …, 2022 - Springer
Extracellular vesicles (EVs) are advanced therapeutic strategies that can be used to
efficiently treat diseases. Promising features of EVs include their innate therapeutic …

Surface engineering of HEK293 cell-derived extracellular vesicles for improved pharmacokinetic profile and targeted delivery of IL-12 for the treatment of …

J Zhang, H Song, Y Dong, G Li, J Li, Q Cai… - International journal …, 2023 - Taylor & Francis
Background Extracellular vesicles (EVs) are considered a promising drug delivery platform.
Naïve EVs face numerous issues that limit their applications, such as fast clearance, hepatic …

An ECM-mimetic hydrogel to promote the therapeutic efficacy of osteoblast-derived extracellular vesicles for bone regeneration

K Man, MY Brunet, AS Federici, DA Hoey… - … in bioengineering and …, 2022 - frontiersin.org
The use of extracellular vesicles (EVs) is emerging as a promising acellular approach for
bone regeneration, overcoming translational hurdles associated with cell-based therapies …

[HTML][HTML] Development of an injectable alginate-collagen hydrogel for cardiac delivery of extracellular vesicles

P Gil-Cabrerizo, L Saludas, F Prósper… - International Journal of …, 2022 - Elsevier
Extracellular vesicles (EVs) are nanosized particles with attractive therapeutic potential for
cardiac repair. However, low retention and stability after systemic administration limit their …

Endometrial small extracellular vesicles regulate human trophectodermal cell invasion by reprogramming the phosphoproteome landscape

M Fatmous, A Rai, QH Poh, LA Salamonsen… - Frontiers in Cell and …, 2022 - frontiersin.org
A series of cyclical events within the uterus are crucial for pregnancy establishment. These
include endometrial regeneration following menses, under the influence of estrogen …