Cannabinoid receptor subtype 2 (CB2R) in a multitarget approach: perspective of an innovative strategy in cancer and neurodegeneration
GF Mangiatordi, F Intranuovo, P Delre… - Journal of Medicinal …, 2020 - ACS Publications
The cannabinoid receptor subtype 2 (CB2R) represents an interesting and new therapeutic
target for its involvement in the first steps of neurodegeneration as well as in cancer onset …
target for its involvement in the first steps of neurodegeneration as well as in cancer onset …
Targeting the Endocannabinoid System Present in the Glioblastoma Tumour Microenvironment as a Potential Anti-Cancer Strategy
The highly aggressive and invasive glioblastoma (GBM) tumour is the most malignant lesion
among adult-type diffuse gliomas, representing the most common primary brain tumour in …
among adult-type diffuse gliomas, representing the most common primary brain tumour in …
Development of the High-Affinity Carborane-Based Cannabinoid Receptor Type 2 PET Ligand [18F]LUZ5-d8
L Ueberham, D Gündel, M Kellert… - Journal of Medicinal …, 2023 - ACS Publications
The development of cannabinoid receptor type 2 (CB2R) radioligands for positron emission
tomography (PET) imaging was intensively explored. To overcome the low metabolic …
tomography (PET) imaging was intensively explored. To overcome the low metabolic …
[引用][C] Goods and bads of the endocannabinoid system as a therapeutic target: Lessons learned after 30 years
Lighting up the plasma membrane: development and applications of fluorescent ligands for transmembrane proteins
C Borgarelli, YE Klingl… - … A European Journal, 2021 - Wiley Online Library
Despite the fact that transmembrane proteins represent the main therapeutic targets for
decades, complete and in‐depth knowledge about their biochemical and pharmacological …
decades, complete and in‐depth knowledge about their biochemical and pharmacological …
N-Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of …
F Intranuovo, M Majellaro… - Journal of Medicinal …, 2024 - ACS Publications
Cannabinoid receptor subtype 2 (CB2R) is emerging as a pivotal biomarker to identify the
first steps of inflammation-based diseases such as cancer and neurodegeneration. There is …
first steps of inflammation-based diseases such as cancer and neurodegeneration. There is …
Fenchone Derivatives as a Novel Class of CB2 Selective Ligands: Design, Synthesis, X-ray Structure and Therapeutic Potential
R Smoum, C Haj, S Hirsch, A Nemirovski, Z Yekhtin… - Molecules, 2022 - mdpi.com
A series of novel cannabinoid-type derivatives were synthesized by the coupling of (1S, 4R)-
(+) and (1R, 4S)-(−)-fenchones with various resorcinols/phenols. The fenchone-resorcinol …
(+) and (1R, 4S)-(−)-fenchones with various resorcinols/phenols. The fenchone-resorcinol …
The literature of heterocyclic chemistry, Part XXI, 2021
LI Belen'kii, GA Gazieva, YB Evdokimenkova… - Advances in …, 2024 - Elsevier
A systematized survey of reviews and monographs published in 2021 on all aspects of
heterocyclic chemistry is given. Methods for the synthesis, reactivity, and practically useful …
heterocyclic chemistry is given. Methods for the synthesis, reactivity, and practically useful …
Rational Design, Synthesis, and Evaluation of Fluorescent CB2 Receptor Ligands for Live-Cell Imaging: A Comprehensive Review
P Bhattacharjee, MR Iyer - Pharmaceuticals, 2023 - mdpi.com
The cannabinoid receptors CB1 and CB2 are class AG protein-coupled receptors (GPCRs)
that are activated via endogenous lipids called endocannabinoids. The endocannabinoid …
that are activated via endogenous lipids called endocannabinoids. The endocannabinoid …
Discovery of a Cannabinoid CB2 Receptor Fluorescent Probe Based on a Pyridin-2-yl-benzyl-imidazolidine-2, 4-dione Scaffold
LV de Paus, APA Janssen, A Halimi, RJ van den Berg… - Synlett, 2024 - thieme-connect.com
Cannabinoid receptor type 2 (CB 2 R) agonists have therapeutic potential for the treatment
of (neuro) inflammatory diseases. Fluorescent probes enable the detection of CB 2 R in …
of (neuro) inflammatory diseases. Fluorescent probes enable the detection of CB 2 R in …