Unique, functional, homodimeric heavy chain–only antibodies, devoid of light chains, are
circulating in the blood of Camelidae. These antibodies recognize their cognate antigen via …

A nanobody (Nb) is a registered trademark of Ablynx, referring to the single antigen‐binding
domain of heavy chain‐only antibodies (HCAbs) that are circulating in Camelidae. Nbs are …

In the mammalian nervous system, billions of neurons connected by quadrillions of
synapses exchange electrical, chemical and mechanical signals. Disruptions to this network …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

Chimeric antigen receptor (CAR)-expressing T cells targeting surface-bound tumor antigens
have yielded promising clinical outcomes, with two CD19 CAR-T cell therapies recently …

Since the serendipitous discovery 20 years ago of bona fide camelid heavy-chain
antibodies, their single-domain antigen-binding fragments, known as VHHs or nanobodies …

Antibodies are key reagents to investigate cellular processes. The development of
recombinant antibodies and binders derived from natural protein scaffolds has expanded …

Owing to peculiar properties of nanobody, including nanoscale size, robust structure, stable
and soluble behaviors in aqueous solution, reversible refolding, high affinity and specificity …

Reagents that bind tightly and specifically to biomolecules of interest remain essential in the
exploration of biology and in their ultimate application to medicine. Besides ligands for …

Nanobodies are antibody fragments derived from camelids, naturally endowed with
properties like low molecular weight, high affinity and low immunogenicity, which contribute …