Genetically engineered mouse models of melanoma
Melanoma is a complex disease that exhibits highly heterogeneous etiological,
histopathological, and genetic features, as well as therapeutic responses. Genetically …
histopathological, and genetic features, as well as therapeutic responses. Genetically …
Melanocyte stem cell activation and translocation initiate cutaneous melanoma in response to UV exposure
Melanoma is one of the deadliest cancers, yet the cells of origin and mechanisms of tumor
initiation remain unclear. The majority of melanomas emerge from clear skin without a …
initiation remain unclear. The majority of melanomas emerge from clear skin without a …
Mouse cutaneous melanoma induced by mutant BRaf arises from expansion and dedifferentiation of mature pigmented melanocytes
To identify the cells at the origin of melanoma, we combined single-cell lineage-tracing and
transcriptomics approaches with time-lapse imaging. A mouse model that recapitulates key …
transcriptomics approaches with time-lapse imaging. A mouse model that recapitulates key …
Gastrointestinal stress as innate defence against microbial attack
The human gastrointestinal (GI) tract has been bestowed with the most difficult task of
protecting the underlying biological compartments from the resident commensal flora and …
protecting the underlying biological compartments from the resident commensal flora and …
CD34 defines melanocyte stem cell subpopulations with distinct regenerative properties
SS Joshi, B Tandukar, L Pan, JM Huang, F Livak… - PLoS …, 2019 - journals.plos.org
Melanocyte stem cells (McSCs) are the undifferentiated melanocytic cells of the mammalian
hair follicle (HF) responsible for recurrent generation of a large number of differentiated …
hair follicle (HF) responsible for recurrent generation of a large number of differentiated …
Sexual dimorphism in melanocyte stem cell behavior reveals combinational therapeutic strategies for cutaneous repigmentation
L An, D Kim, LR Donahue, MA Mejooli, CY Eom… - Nature …, 2024 - nature.com
Vitiligo is an autoimmune skin disease caused by cutaneous melanocyte loss. Although
phototherapy and T cell suppression therapy have been widely used to induce epidermal re …
phototherapy and T cell suppression therapy have been widely used to induce epidermal re …
Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathways
The cyclic AMP pathway promotes melanocyte differentiation by activating CREB and the
cAMP-regulated transcription co-activators 1–3 (CRTC1–3). Differentiation is dysregulated …
cAMP-regulated transcription co-activators 1–3 (CRTC1–3). Differentiation is dysregulated …
BMI1 is required for melanocyte stem cell maintenance and hair pigmentation
MM Wilson, PS Danielian, G Salus… - Pigment Cell & …, 2023 - Wiley Online Library
The epigenetic repressor BMI1 plays an integral role in promoting the self‐renewal and
proliferation of many adult stem cell populations, and also tumor types, primarily through …
proliferation of many adult stem cell populations, and also tumor types, primarily through …
Dynamic regulation of chromatin accessibility during melanocyte stem cell activation
S Lee, L An, PD Soloway… - Pigment Cell & Melanoma …, 2023 - Wiley Online Library
Melanocyte stem cells (McSCs) of the hair follicle are necessary for hair pigmentation and
can serve as melanoma cells of origin when harboring cancer‐driving mutations. McSCs …
can serve as melanoma cells of origin when harboring cancer‐driving mutations. McSCs …
Macroenvironment-gene-microenvironment interactions in ultraviolet radiation-induced melanomagenesis
Cutaneous malignant melanoma is one of the few major cancers that continue to exhibit a
positive rate of increase in the developed world. A wealth of epidemiological data has …
positive rate of increase in the developed world. A wealth of epidemiological data has …