Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional
states throughout organism development. Epigenetics modifications, such as DNA …

The formation and maintenance of the epidermis depend on epidermal stem cell
differentiation and must be tightly regulated. Epigenetic mechanisms such as DNA …

Background: Detecting DNA-binding proteins (DBPs) based on biological and chemical
methods is time-consuming and expensive. Objective: In recent years, the rise of …

Abstract N6-methyladenosine (m6A) is the methylation of the adenosine at the nitrogen-6
position, which is the most abundant RNA methylation modification and involves a series of …

With the development of computer technology, many machine learning algorithms have
been applied to the field of biology, forming the discipline of bioinformatics. Protein function …

Cyclin proteins are capable to regulate the cell cycle by forming a complex with cyclin-
dependent kinases to activate cell cycle. Correct recognition of cyclin proteins could provide …

Excessive oxidative stress responses can threaten our health, and thus it is essential to
produce antioxidant proteins to regulate the body's oxidative responses. The low number of …

Natural antioxidant proteins are mainly found in plants and animals, which interact to
eliminate excessive free radicals and protect cells and DNA from damage, prevent and treat …

N2-methylguanosine is a post-transcriptional modification of RNA that is found in eukaryotes
and archaea. The biological function of m2G modification discovered so far is to control and …

Underlying mechanisms of cardiovascular diseases (CVD) have been investigated for over
100 years and novel molecular level mechanisms in the pathophysiology are still …