In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM,
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …

One way to preserve a rare book is to lock it away from all potential sources of damage. Of
course, an inaccessible book is also of little use, and the paper and ink will continue to …

Oncogene activation disturbs cellular processes and accommodates a complex landscape
of changes in the genome that contribute to genomic instability, which accelerates mutation …

From bacteria to mammalian cells, damaged DNA is sensed and targeted by DNA repair
pathways. In eukaryotes, kinases play a central role in coordinating the DNA damage …

The chemical treatment of cancer started with the realization that DNA damaging agents
such as mustard gas present notable antitumoural properties. Consequently, early drug …

Hydroxyurea (HU) is mostly referred to as an inhibitor of ribonucleotide reductase (RNR)
and as the agent that is commonly used to arrest cells in the S-phase of the cycle by …

The interplay between replication stress and the S phase checkpoint is a key determinant of
genome maintenance, and has a major impact on human diseases, notably, tumour …

The ATR-Chk1 pathway is critical for DNA damage responses and cell-cycle progression.
Chk1 inhibition is more deleterious to cycling cells than ATR inhibition, raising questions …

Chromosomal instability (CIN) is associated with many human diseases, including
neurodevelopmental or neurodegenerative conditions, age-related disorders and cancer …

R loops arising during transcription induce genomic instability, but how cells respond to the
R loop-associated genomic stress is still poorly understood. Here, we show that cells …