A decade ago, we hypothesized that drug addiction can be viewed as a transition from
voluntary, recreational drug use to compulsive drug-seeking habits, neurally underpinned by …

Drug addiction is a chronically relapsing disorder that has been characterized by (1)
compulsion to seek and take the drug,(2) loss of control in limiting intake, and (3) emergence …

Science fiction notions of altering problematic memories are starting to become reality as
techniques emerge through which unique memories can be edited. Here we review memory …

It was suggested in 1986 that cue-induced drug craving in cocaine addicts progressively
increases over the first several weeks of abstinence and remains high for extended periods …

Background and rationale Results from many clinical studies suggest that drug relapse and
craving are often provoked by acute exposure to the self-administered drug or related drugs …

Drug use and relapse involve learned associations between drug-associated environmental
cues and drug effects. Extinction procedures in the clinic can suppress conditioned …

Background Tobacco smoking is the leading cause of preventable death in developed
countries. Our previous studies in animal models and humans suggest that repeated …

Consolidated memories can re-enter states of transient instability following reactivation, from
which they must again stabilize in order to persist, contradicting the previously dominant …

This review discusses the evidence for the hypothesis that the development of drug
addiction can be understood in terms of interactions between Pavlovian and instrumental …

Memory reconsolidation has been argued to be a distinct process that serves to maintain,
strengthen or modify memories. Specifically, the retrieval of a previously consolidated …