Akt kinase, a member of AGC kinases, is important in many cellular functions including
proliferation, migration, cell growth and metabolism. There are three known Akt isoforms …

The release of reactive oxygen species (ROS) and the generation of oxidative stress are
considered critical factors for the pathogenesis of diabetes mellitus (DM), a disorder that is …

Neurodegenerative disorders are significantly increasing in incidence as the age of the
global population continues to climb with improved life expectancy. At present, more than 30 …

Summary The PI3K/AKT signaling cascade is one of the most commonly dysregulated
pathways in cancer, with over half of tumors exhibiting aberrant AKT activation. Although …

The current outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2), termed coronavirus disease 2019 (COVID-19), has generated a notable challenge …

ELABELA (ELA) is a peptide hormone required for heart development that signals via the
Apelin Receptor (APLNR, APJ). ELA is also abundantly secreted by human embryonic stem …

The mammalian target of rapamycin (mTOR), the key component of the protein complexes
mTORC1 and mTORC2, plays a critical role in cellular development, tissue regeneration …

Multiple viral pathogens can pose a significant health risk to individuals. As a recent
example, the β-coronavirus family virion, SARS-CoV-2, has quickly evolved as a pandemic …

Akt is a central player in the signal transduction pathways activated in response to many
growth factors, hormones, cytokines, and nutrients and is thought to control a myriad of …

The global increase in lifespan noted not only in developed nations, but also in large
developing countries parallels an observed increase in a significant number of non …