Cancer cells originate from a series of acquired genetic mutations that can drive their
uncontrolled cell proliferation and immune evasion. Environmental factors, including the …

Over the past several decades, the incidence of early-onset cancers, often defined as
cancers diagnosed in adults< 50 years of age, in the breast, colorectum, endometrium …

Historically, cancer research and therapy have focused on malignant cells and their tumor
microenvironment. However, the vascular, lymphatic and nervous systems establish long …

Groundwater supplies are progressively being degraded by anthropogenic pollution,
making it challenging to meet the Sustainable Development Goals (SDGs) of access to safe …

EFSA was asked for a scientific opinion on the risks to public health related to the presence
of N‐nitrosamines (N‐NAs) in food. The risk assessment was confined to those 10 …

Background Epidemiological evidence in multiple jurisdictions has shown an association
between nitrate exposure in drinking water and an increased risk of colorectal cancer …

Simple Summary In this cross-sectional study, the global incidence, death, and DALY rates
of early-onset colorectal cancer (CRC) increased from 1990 to 2019, with large variations in …

Modernization of society from a rural, hunter-gatherer setting into an urban and industrial
habitat, with the associated dietary changes, has led to an increased prevalence of …

Multiple Myeloma (MM) remains an incurable plasma cell neoplasm. Although little is known
about the etiology of MM, several metabolic risk factors such as obesity, diabetes mellitus …

Diet and exercise are modifiable lifestyle factors known to have a major influence on
metabolism. Clinical practice addresses diseases of altered metabolism such as diabetes or …