An update on current therapeutic drugs treating COVID-19

R Wu, L Wang, HCD Kuo, A Shannar, R Peter… - Current pharmacology …, 2020 - Springer
The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has presented unprecedented …

[HTML][HTML] Natural history of COVID-19 and current knowledge on treatment therapeutic options

WG Dos Santos - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Despite intense research there is currently no effective vaccine available against the new
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged in the later 2019 …

Angiotensin receptor blockers as tentative SARS‐CoV‐2 therapeutics

D Gurwitz - Drug development research, 2020 - Wiley Online Library
At the time of writing this commentary (February 2020), the coronavirus COVID‐19 epidemic
has already resulted in more fatalities compared with the SARS and MERS coronavirus …

COVID-19 and individual genetic susceptibility/receptivity: role of ACE1/ACE2 genes, immunity, inflammation and coagulation. Might the double X-chromosome in …

D Gemmati, B Bramanti, ML Serino… - International journal of …, 2020 - mdpi.com
In December 2019, a novel severe acute respiratory syndrome (SARS) from a new
coronavirus (SARS-CoV-2) was recognized in the city of Wuhan, China. Rapidly, it became …

Harnessing nitric oxide for preventing, limiting and treating the severe pulmonary consequences of COVID-19

NC Adusumilli, D Zhang, JM Friedman, AJ Friedman - Nitric oxide, 2020 - Elsevier
The ongoing outbreak of COVID-19 has quickly become a daunting challenge to global
health. In the absence of targeted therapy and a reported 5.5% case fatality rate in the …

Is antioxidant therapy a useful complementary measure for Covid-19 treatment? An algorithm for its application

ME Soto, V Guarner-Lans, E Soria-Castro… - Medicina, 2020 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes the corona virus
disease-19 which is accompanied by severe pneumonia, pulmonary alveolar collapses and …

Genetic hypothesis and pharmacogenetics side of renin-angiotensin-system in COVID-19

D Gemmati, V Tisato - Genes, 2020 - mdpi.com
The importance of host genetics and demography in coronavirus disease 2019 (COVID-19)
is a crucial aspect of infection, prognosis and associated case fatality rate. Individual genetic …

p53/NF-kB balance in SARS-CoV-2 infection: From OMICs, genomics and pharmacogenomics insights to tailored therapeutic perspectives (COVIDomics)

D Milani, L Caruso, E Zauli, AM Al Owaifeer… - Frontiers in …, 2022 - frontiersin.org
SARS-CoV-2 infection affects different organs and tissues, including the upper and lower
airways, the lung, the gut, the olfactory system and the eye, which may represent one of the …

Drug Repurposing for Candidate SARS-CoV-2 Main Protease Inhibitors by a Novel In Silico Method

M Sencanski, V Perovic, SB Pajovic, M Adzic… - Molecules, 2020 - mdpi.com
The SARS-CoV-2 outbreak caused an unprecedented global public health threat, having a
high transmission rate with currently no drugs or vaccines approved. An alternative powerful …

SARS‐CoV‐2, early entry events

JP Chambers, J Yu, JJ Valdes… - Journal of …, 2020 - Wiley Online Library
Viruses are obligate intracellular parasites, and host cell entry is the first step in the viral life
cycle. The SARS‐CoV‐2 (COVID‐19) entry process into susceptible host tissue cells is …