A review of the pharmacological activities and recent synthetic advances of γ-butyrolactones

J Hur, J Jang, J Sim - International Journal of Molecular Sciences, 2021 - mdpi.com
γ-Butyrolactone, a five-membered lactone moiety, is one of the privileged structures of
diverse natural products and biologically active small molecules. Because of their broad …

Biological activity of selected natural and synthetic terpenoid lactones

AK Surowiak, L Balcerzak, S Lochyński… - International journal of …, 2021 - mdpi.com
Terpenoids with lactone moieties have been indicated to possess high bioactivity. Certain
terpenoid lactones exist in nature, in plants and animals, but they can also be obtained by …

I2-Mediated Oxidative C–N Bond Formation for Metal-Free One-Pot Synthesis of Di-, Tri-, and Tetrasubstituted Pyrazoles from α,β-Unsaturated Aldehydes/Ketones …

X Zhang, J Kang, P Niu, J Wu, W Yu… - The Journal of organic …, 2014 - ACS Publications
An I2-mediated metal-free oxidative C–N bond formation methodology has been established
for the regioselective pyrazole synthesis. This practical and eco-friendly one-pot protocol …

One-pot, three-component approach to the synthesis of 3, 4, 5-trisubstituted pyrazoles

A Kamal, KNV Sastry, D Chandrasekhar… - The Journal of …, 2015 - ACS Publications
An operationally simple and high yielding protocol for the synthesis of polyfunctional
pyrazoles has been developed through one-pot, three-component coupling of aldehydes, 1 …

Gold-catalyzed tandem dual heterocyclization of enynones with 1, 3, 5-triazines: bicyclic furan synthesis and mechanistic insights

Y Zheng, Y Chi, M Bao, L Qiu, X Xu - The Journal of Organic …, 2017 - ACS Publications
A general and unprecedented gold-catalyzed tandem dual heterocyclization reaction of
enynones with 1, 3, 5-triazines has been developed, which provides bicyclic fused furans in …

Synthesis, antiproliferative and cytotoxic activities, DNA binding features and molecular docking study of novel enamine derivatives

M Burcu Gürdere, A Aydin, B Yencilek… - Chemistry & …, 2020 - Wiley Online Library
Novel enamine derivatives were synthesized from the reaction of lactone and chalcones and
their antiproliferative and cytotoxic activities against six cancer cell lines (eg, HeLa, HT29 …

The role of chirality in a set of key intermediates of pharmaceutical interest, 3-aryl-substituted-γ-butyrolactones, evidenced by chiral HPLC separation and by …

D Rossi, R Nasti, S Collina, G Mazzeo… - … of Pharmaceutical and …, 2017 - Elsevier
The enantiomers of four chiral 3-aryl-substituted-γ-butyrolactones, key intermediates for the
preparation of compounds of pharmaceutical interest, were successfully isolated by …

Structural investigation of interactions between halogenated flavonoids and the lipid membrane along with their role as cytotoxic agents

A Dudek, N Szulc, A Pawlak, P Strugała-Danak… - Scientific Reports, 2024 - nature.com
This study focuses on understanding the structural and molecular changes in lipid
membranes under the influence of six halogenated flavonoid derivatives differing in the …

Sequential two‐step stereoselective amination of allylic alcohols through the combination of laccases and amine transaminases

J Albarrán‐Velo, I Lavandera… - …, 2020 - Wiley Online Library
A sequential two‐step chemoenzymatic methodology for the stereoselective synthesis of
(3E)‐4‐(het) arylbut‐3‐en‐2‐amines in a highly selective manner and under mild reaction …

Synthesis of 3-Carbonyl Trisubstituted Furans via Pd-Catalyzed Aerobic Cycloisomerization Reaction: Development and Mechanistic Studies

AA Barboza, AC Neto, IG Rosset… - The Journal of …, 2021 - ACS Publications
Herein, we report the synthesis of 3-carbonyl-trisubstituted furans via Pd-catalyzed oxidative
cycloisomerization reactions of 2-alkenyl-1, 3-dicarbonyl scaffolds, using molecular oxygen …