Kinins are among the most potent autacoids involved in inflammatory, vascular and pain
processes. These short-lived peptides, including bradykinin, kallidin and T-kinin, are …

The direction that research takes for a particular mediator is often dictated by the
circumstances of its discovery. In the case of the kinins, it was soon realised that bradykinin …

Kinins (bradykinin, kallidin) are produced at sites of injury and inflammation and serve a
critical role in signaling tissue distress as well as organising tissue responsiveness to injury …

Bradykinin has long been known to exist in the central nervous system and has been
hypothesized to mediate specific functions. Despite an increasing understanding of the …

Bradykinin‐like activity was purified from acetic acid extracts of saline‐perfused rat brains by
gel filtration chromatography and two reverse‐phase HPLC systems capable of resolving …

Publisher Summary This chapter reviews substantial anatomical data describing the
distribution of bradykinin (BK) receptors as well as that of the biochemical machinery for the …

We studied whether the components of the kallikrein-kinin system are present in the central
nervous system. We found that human cerebrospinal fluid (CSF) contains free kinins: 53±15 …

The great physiologic importance of the kinin system has prompted much investigation,
during the last decade, of the chemistry, pharmacology and physiology of the peptides which …

Bradykinin B2 receptors were localized in the sheep brain and spinal cord by quantitative in
vitro autoradiography using a radiolabelled and specific bradykinin B2 receptor antagonist …

The effect of central injection of selective kinin B1 and B2 receptor antagonists on the febrile
response induced by endotoxin (E. coli lipopolysaccharide, LPS) in rats was investigated …