[HTML][HTML] Surgical therapy in osteoarthritis

H Madry - Osteoarthritis and cartilage, 2022 - Elsevier
Objective To provide an evidence-based overview of the different surgical procedures in
osteoarthritis (OA). Design This narrative review reports on surgical therapies (1) for severe …

[HTML][HTML] Size of cartilage defects and the need for repair: a systematic review

M Husen, RJH Custers, M Hevesi, AJ Krych… - Journal of Cartilage & …, 2022 - Elsevier
Background Cartilage defects are treated with a wide array of non-operative and surgical
procedures. Optimal choice of treatment depends on lesion depth and size. Objectives To …

Hydrogel-based matrix-associated autologous chondrocyte implantation shows greater substantial clinical benefit at 24 months follow-up than microfracture: a …

C Gaissmaier, P Angele, RC Spiro, A Köhler… - Cartilage, 2024 - journals.sagepub.com
Objective To compare substantial clinical benefit (SCB) of a hydrogel-based, matrix-
associated autologous chondrocyte implantation (M-ACI) method versus microfracture (MFx) …

Biomimetic melatonin-loaded silk fibroin/GelMA scaffold strengthens cartilage repair through retrieval of mitochondrial functions

M Hou, Y Zhang, Y Liu, X Ge, X Hu, Z Zhao… - Journal of Materials …, 2023 - Elsevier
Articular cartilage injury induced by collision or trauma is a common sports-related condition
that may progress to pain, dysfunction, and secondary osteoarthritis (OA). Limited by self …

Comparison of hydrogel-based autologous chondrocyte implantation versus microfracture: a propensity score matched-pair analysis

P Niemeyer, P Angele, RC Spiro… - … Journal of Sports …, 2023 - journals.sagepub.com
Background: Few studies exist for large defects comparing matrix-associated autologous
chondrocyte implantation (M-ACI) with other cartilage repair methods due to the limited …

[HTML][HTML] Arthroscopic shaver-based harvest of minced cartilage results in reduced chondrocyte viability and reduced quality of cartilaginous repair tissue compared …

J Frings, A Baranowsky, A Korthaus… - … : The Journal of …, 2024 - Elsevier
Purpose To characterize and compare the quality of regenerative cartilage tissue (ReCT)
after conventional minced cartilage (CMC) and arthroscopic minced cartilage (AMC), in …

Arthroscopic Management of Moderate-to-Severe Osteoarthritis of the Knee: A Systematic Review

SC Petterson, JE Brite, ES Jelen, KH Wang… - JBJS …, 2024 - journals.lww.com
Background: Total knee arthroplasty (TKA) is the procedure of choice for osteoarthritis of the
knee (OAK) when conservative treatment fails; however, high rates of dissatisfaction and …

[HTML][HTML] Scaffold-associated procedures are superior to microfracture in managing focal cartilage defects in the knee: A systematic review & meta-analysis

S Seewoonarain, D Ganesh, E Perera, R Popat… - The Knee, 2023 - Elsevier
Background Debate continues as to whether surgical treatment with chondral-regeneration
devices is superior to microfracture for focal articular cartilage defects in the knee. Purpose …

HWJMSC-EVs promote cartilage regeneration and repair via the ITGB1/TGF-β/Smad2/3 axis mediated by microfractures

Z Chen, T Zhou, H Luo, Z Wang, Q Wang, R Shi… - Journal of …, 2024 - Springer
The current first-line treatment for repairing cartilage defects in clinical practice is the
creation of microfractures (MF) to stimulate the release of mesenchymal stem cells (MSCs); …

The Statistical Fragility of Marrow Stimulation for Cartilage Defects of the Knee: A Systematic Review of Randomized Controlled Trials

A Yendluri, A Alexanian, RR Chari, JJ Corvi… - Cartilage, 2024 - journals.sagepub.com
Objective Marrow stimulation is used to address knee cartilage defects. In this study, we
used the fragility index (FI), reverse fragility index (rFI), and fragility quotient (FQ) to evaluate …