Obesity: pathophysiology and management

KM Gadde, CK Martin, HR Berthoud… - Journal of the American …, 2018 - jacc.org
Obesity continues to be among the top health concerns across the globe. Despite our failure
to contain the high prevalence of obesity, we now have a better understanding of its …

Brain insulin resistance at the crossroads of metabolic and cognitive disorders in humans

S Kullmann, M Heni, M Hallschmid… - Physiological …, 2016 - journals.physiology.org
Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …

Physiological adaptations to weight loss and factors favouring weight regain

FL Greenway - International journal of obesity, 2015 - nature.com
Obesity is a major global health problem and predisposes individuals to several
comorbidities that can affect life expectancy. Interventions based on lifestyle modification (for …

[HTML][HTML] Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity

D Val-Laillet, E Aarts, B Weber, M Ferrari… - NeuroImage: Clinical, 2015 - Elsevier
Functional, molecular and genetic neuroimaging has highlighted the existence of brain
anomalies and neural vulnerability factors related to obesity and eating disorders such as …

Uncontrolled eating: a unifying heritable trait linked with obesity, overeating, personality and the brain

U Vainik, I García‐García… - European Journal of …, 2019 - Wiley Online Library
Many eating‐related psychological constructs have been proposed to explain obesity and
overeating. However, these constructs, including food addiction, disinhibition, hedonic …

Neural responses to visual food cues according to weight status: a systematic review of functional magnetic resonance imaging studies

KM Pursey, P Stanwell, RJ Callister, K Brain… - Frontiers in …, 2014 - frontiersin.org
Emerging evidence from recent neuroimaging studies suggests that specific food-related
behaviors contribute to the development of obesity. The aim of this review was to report the …

Neural correlates of dietary self-control in healthy adults: a meta-analysis of functional brain imaging studies

JE Han, N Boachie, I Garcia-Garcia, A Michaud… - Physiology & …, 2018 - Elsevier
Self-control is known to influence food intake and body weight. Neuroimaging studies have
used tasks that tap into different aspects of self-control. Here we conducted a coordinate …

Selective insulin resistance in homeostatic and cognitive control brain areas in overweight and obese adults

S Kullmann, M Heni, R Veit, K Scheffler… - Diabetes …, 2015 - Am Diabetes Assoc
OBJECTIVE Impaired brain insulin action has been linked to obesity, type 2 diabetes, and
neurodegenerative diseases. To date, the central nervous effects of insulin in obese humans …

Cognitive and autonomic determinants of energy homeostasis in obesity

D Richard - Nature Reviews Endocrinology, 2015 - nature.com
Obesity ensues from an imbalance between energy intake and expenditure that results from
gene–environment interactions, which favour a positive energy balance. A society that …

Overlapping neural endophenotypes in addiction and obesity

A Michaud, U Vainik, I Garcia-Garcia… - Frontiers in …, 2017 - frontiersin.org
Impulsivity refers to a tendency to act rapidly without full consideration of consequences. The
trait is thought to result from the interaction between high arousal responses to potential …