Role of nuclear factor kappa B (NF-κB) signalling in neurodegenerative diseases: an mechanistic approach

S Singh, TG Singh - Current Neuropharmacology, 2020 - ingentaconnect.com
A transcriptional regulatory nuclear factor kappa B (NF-ΚB) protein is a modulator of cellular
biological activity via binding to a promoter region in the nucleus and transcribing various …

Morin as an imminent functional food ingredient: An update on its enhanced efficacy in the treatment and prevention of metabolic syndromes

K Thakur, YY Zhu, JY Feng, JG Zhang, F Hu… - Food & function, 2020 - pubs.rsc.org
Flavonoids represent polyphenolic plant secondary metabolites with a general structure of a
15-carbon skeleton comprising two phenyl rings and a heterocyclic ring. Over 5000 natural …

Polyphenols with anti-amyloid β aggregation show potential risk of toxicity via pro-oxidant properties

H Kobayashi, M Murata, S Kawanishi… - International Journal of …, 2020 - mdpi.com
Alzheimer's disease (AD) is the most common form of dementia among older people.
Amyloid β (Aβ) aggregation has been the focus for a therapeutic target for the treatment of …

Probing molecular interactions of amylose-morin complex and their effect on antioxidant capacity by 2D solid-state NMR spectroscopy

Y Ma, Z Chen, R Chen, Z Wang, S Zhang, J Chen - Food Chemistry, 2023 - Elsevier
Interaction of polyphenols and starch significantly governed the further applications on
polyphenol-starchy foods. Elucidation of inter-molecular interaction is, however, a challenge …

Model yeast as a versatile tool to examine the antioxidant and anti-ageing potential of flavonoids, extracted from medicinal plants

H Zahoor, K Watchaputi, J Hata… - Frontiers in …, 2022 - frontiersin.org
The demand for the production of herbal extracts for cosmetics, food, and health
supplements, known as plant-based medicine, is rising globally. Incorporating herbal …

Potential of natural flavonols and flavanones in the treatment of ulcerative colitis

C Li, Y Tang, Y Ye, M Zuo, Q Lu - Frontiers in Pharmacology, 2023 - frontiersin.org
Ulcerative colitis (UC) is an inflammatory bowel disease generally characterized by chronic,
persistent, recurrent, and non-specific ulcers of the intestine. Its main clinical manifestations …

Artificial intelligence-driven identification of morin analogues acting as CaV1. 2 channel blockers: Synthesis and biological evaluation

G Carullo, F Falbo, A Ahmed, A Trezza, B Gianibbi… - Bioorganic …, 2023 - Elsevier
Morin is a vasorelaxant flavonoid, whose activity is ascribable to Ca V 1.2 channel blockade
that, however, is weak as compared to that of clinically used therapeutic agents. A …

Morin regulates M1/M2 microglial polarization via NF-κB p65 to alleviate vincristine-induced neuropathic pain

Y Shao, Y Chen, X Lan, J Lu, G Tang… - Drug Design …, 2024 - Taylor & Francis
Background Morin can alleviate vincristine-induced neuropathic pain via inhibiting
neuroinflammation. Microglial cells play an important role in initiating and maintenance of …

Advancements in research on the immune-inflammatory mechanisms mediated by NLRP3 inflammasome in ischemic stroke and the regulatory role of natural plant …

K Yang, L Zeng, Q He, S Wang, H Xu… - Frontiers in Pharmacology, 2024 - frontiersin.org
Ischemic stroke (IS) is a major cause of mortality and disability among adults. Recanalization
of blood vessels to facilitate timely reperfusion is the primary clinical approach; however …

[HTML][HTML] SWATH-based quantitative proteomic analysis of Morus alba L. leaves after exposure to ultraviolet-B radiation and incubation in the dark

Y Li, S Liu, E Shawky, M Tao, A Liu, K Sulaiman… - … of Photochemistry and …, 2022 - Elsevier
Morus alba is a woody shrub of the family Moraceae and used as traditional Chinese
medicine for a long history. Ultraviolet-B (UV-B) radiation, as a kind of abiotic stress factor …