Background Postzygotic activating PIK3CA variants cause several phenotypes within the
PIK3CA-related overgrowth spectrum (PROS). Variant strength, mosaicism level, specific …

Background Although the prognostic outcomes of liver cancer (LC) cases have improved
with the advancement in diagnostic technology and treatment methods, the transferability …

PIK3CA encodes the class I PI3Kα isoform and is frequently mutated in cancer. Activating
mutations in PIK3CA also cause a range of congenital disorders featuring asymmetric tissue …

Background Nigella sativa (N. sativa) exhibits anti-inflammatory, antioxidant, antidiabetic,
antimetastatic and antinociceptive effects and has been used to treat dozens of diseases …

Background Adipose lesions of nerve primarily include intra-and extraneural lipomas and
lipomatosis of nerve (LN). This paper will summarize the advances that have been made in …

The phosphatidylinositol‑3‑kinase catalytic subunit α (PIK3CA) gene is mutated in numerous
human cancers. This mutation promotes the proliferation of tumor cells; however, the …

Macrodactyly is a disabling congenital disease characterized by overgrowth of soft tissues
and bones, which leads to finger enlargement and joint deformity. The mechanism of bone …

(1) Background: Carpal tunnel syndrome (CTS), a compressive mononeuropathy of the
median nerve at the wrist, is rare in childhood and occurs most frequently due to secondary …

Composite hemangioendothelioma (CHE) is considered a borderline malignant vascular
tumor defined by an admixture of distinct vascular neoplastic components. A 21-year-old …

Lipomatosis of peripheral nerves (LPN, also known as fibrolipomatous or lipofibromatous
hamartoma of peripheral nerves) is a very rare, benign, intraneural, tumorous lesion that …