Protein acylation: mechanisms, biological functions and therapeutic targets

S Shang, J Liu, F Hua - Signal Transduction and Targeted Therapy, 2022 - nature.com
Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

Protein palmitoylation and cancer

PJ Ko, SJ Dixon - EMBO reports, 2018 - embopress.org
Protein S‐palmitoylation is a reversible post‐translational modification that alters the
localization, stability, and function of hundreds of proteins in the cell. S‐palmitoylation is …

[HTML][HTML] Selenoprotein K deficiency-induced apoptosis: A role for calpain and the ERS pathway

SZ Jia, XW Xu, ZH Zhang, C Chen, YB Chen… - Redox biology, 2021 - Elsevier
Selenoprotein K (SELENOK), an endoplasmic reticulum (ER) resident protein, is regulated
by dietary selenium and expressed at a relatively high level in neurons. SELENOK has been …

[HTML][HTML] Selenoprotein K knockdown induces apoptosis in skeletal muscle satellite cells via calcium dyshomeostasis-mediated endoplasmic reticulum stress

RF Fan, XW Chen, H Cui, HY Fu, WX Xu, JZ Li, H Lin - Poultry Science, 2023 - Elsevier
Skeletal muscle satellite cells (SMSCs), known as muscle stem cells, play an important role
in muscle embryonic development, post-birth growth, and regeneration after injury …

The role of calcium signaling in melanoma

H Zhang, Z Chen, A Zhang, AA Gupte… - International journal of …, 2022 - mdpi.com
Calcium signaling plays important roles in physiological and pathological conditions,
including cutaneous melanoma, the most lethal type of skin cancer. Intracellular calcium …

Molecular mechanisms by which selenoprotein K regulates immunity and cancer

MP Marciel, PR Hoffmann - Biological Trace Element Research, 2019 - Springer
Many of the 25 members of the selenoprotein family function as enzymes that utilize their
selenocysteine (Sec) residues to catalyze redox-based reactions. However, some …

Implications of a neuronal receptor family, metabotropic glutamate receptors, in cancer development and progression

K Eddy, MN Eddin, A Fateeva, SVB Pompili, R Shah… - Cells, 2022 - mdpi.com
Cancer is the second leading cause of death, and incidences are increasing globally.
Simply defined, cancer is the uncontrolled proliferation of a cell, and depending on the …

Role of selenoprotein P expression in the function of pancreatic β cells: Prevention of ferroptosis-like cell death and stress-induced nascent granule degradation

N Kitabayashi, S Nakao, Y Mita, K Arisawa… - Free Radical Biology …, 2022 - Elsevier
Selenoprotein P (SELENOP) is a major selenium (Se)-containing protein (selenoprotein) in
human plasma that is mainly synthesized in the liver. SELENOP transports Se to the cells …

Potential relationship between the selenoproteome and cancer

Y Jia, J Dai, Z Zeng - Molecular and clinical oncology, 2020 - spandidos-publications.com
The role of the selenoproteome, which is the collection of all proteins containing selenium in
an organism, in cancer development, growth and progression requires further investigation …

Store-Operated calcium entry and its implications in cancer stem cells

I Jardin, JJ Lopez, J Sanchez-Collado, LJ Gomez… - Cells, 2022 - mdpi.com
Tumors are composed by a heterogeneous population of cells. Among them, a sub-
population of cells, termed cancer stem cells, exhibit stemness features, such as self …