Regulation and function of transposable elements in cancer genomes
Over half of human genomic DNA is composed of repetitive sequences generated
throughout evolution by prolific mobile genetic parasites called transposable elements …
throughout evolution by prolific mobile genetic parasites called transposable elements …
From the genome's perspective: Bearing somatic retrotransposition to leverage the regulatory potential of L1 RNAs
D Mangoni, A Mazzetti, F Ansaloni, A Simi… - …, 2024 - Wiley Online Library
Transposable elements (TEs) are mobile genomic elements constituting a big fraction of
eukaryotic genomes. They ignite an evolutionary arms race with host genomes, which in turn …
eukaryotic genomes. They ignite an evolutionary arms race with host genomes, which in turn …
LINE-1 retrotransposons contribute to mouse PV interneuron development
GO Bodea, JM Botto, ME Ferreiro… - Nature …, 2024 - nature.com
Retrotransposons are mobile DNA sequences duplicated via transcription and reverse
transcription of an RNA intermediate. Cis-regulatory elements encoded by retrotransposons …
transcription of an RNA intermediate. Cis-regulatory elements encoded by retrotransposons …
DNA methylation governs the sensitivity of repeats to restriction by the HUSH-MORC2 corepressor
N Pandiloski, V Horváth, O Karlsson… - Nature …, 2024 - nature.com
The human silencing hub (HUSH) complex binds to transcripts of LINE-1 retrotransposons
(L1s) and other genomic repeats, recruiting MORC2 and other effectors to remodel …
(L1s) and other genomic repeats, recruiting MORC2 and other effectors to remodel …
Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons
M Michel, M Heidary, A Mechri, K Da Silva… - Clinical Cancer …, 2024 - aacrjournals.org
Purpose: The detection of ctDNA, which allows noninvasive tumor molecular profiling and
disease follow-up, promises optimal and individualized management of patients with cancer …
disease follow-up, promises optimal and individualized management of patients with cancer …
Transposable element 5mC methylation state of blood cells predicts age and disease
Transposable elements (TEs) are DNA sequences that expand selfishly in the genome,
possibly causing severe cellular damage. While normally silenced, TEs have been shown to …
possibly causing severe cellular damage. While normally silenced, TEs have been shown to …
How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health
A Akhatova, C Jones, K Coward, M Yeste - Clinical Epigenetics, 2025 - Springer
Recent studies support the influence of paternal lifestyle and diet before conception on the
health of the offspring via epigenetic inheritance through sperm DNA methylation, histone …
health of the offspring via epigenetic inheritance through sperm DNA methylation, histone …
[PDF][PDF] On genocentricity and genomocentricity in basic living systems: microorganisms, plants, animals
VI Glazko, GY Kosovsky, TT Glazko - Sel'skokhozyaistvennaya …, 2024 - researchgate.net
The development of genomics and pangenomics is becoming increasingly relevant for the
development of new methods for solving traditional problems of control and directed …
development of new methods for solving traditional problems of control and directed …
LINE-1, the NORth star of nucleolar organization
M Matsuo, G Cristofari - Genes & Development, 2025 - genesdev.cshlp.org
Abstract Long interspersed element-1 (LINE-1) retrotransposons are abundant transposable
elements in mammals and significantly influence chromosome structure, chromatin …
elements in mammals and significantly influence chromosome structure, chromatin …
Endogenous retroelements in hematological malignancies: From epigenetic dysregulation to therapeutic targeting
M Chour, F Porteu, S Depil… - American Journal of …, 2025 - Wiley Online Library
Endogenous retroelements (EREs), which comprise half of the human genome, play a
pivotal role in genome dynamics. Some EREs retained the ability to encode proteins …
pivotal role in genome dynamics. Some EREs retained the ability to encode proteins …