Most eukaryotes require oxygen for their survival and, with increasing multicellular
complexity, oxygen availability and delivery rates vary across the tissues of complex …

Tumor-associated macrophages (TAMs) are integral to the tumor microenvironment (TME),
influencing cancer progression significantly. Attracted by cancer cell signals, TAMs exhibit …

Abstract Type 1 diabetes (T1D) is a common autoimmune disease in which dysregulated
glucose metabolism is a key feature. T1D is both poorly understood and in need of improved …

Introduction Chimeric antigen receptor (CAR) T-cells have emerged as a ground-breaking
therapy for the treatment of hematological malignancies due to their capacity for rapid tumor …

The manufacturing of autologous chimaeric antigen receptor (CAR) T cells largely relies
either on fed-batch and manual processes that often lack environmental monitoring and …

Although cancer has long been considered a genetic disease, increasing evidence shows
that epigenetic aberrations play a crucial role in affecting tumor biology and therapeutic …

Cutaneous leishmaniasis caused by Leishmania parasites exhibits a wide range of clinical
manifestations. Although parasites influence disease severity, cytolytic CD8 T cell responses …

With investigators looking to expand engineered T cell therapies such as CAR-T to new
tumor targets and patient populations, a variety of cell manufacturing platforms have been …

Immunotherapy has been extensively utilized and studied as a prominent therapeutic
strategy for tumors. However, the presence of a hypoxic immunosuppressive tumor …

Many cancer immunotherapies rely on robust CD8+ T cells capable of eliminating cancer
cells and establishing long-term tumor control. Recent insights into immunometabolism …